Vitamin D Supplementation and Breast Cancer Prevention: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Francesca Sperati, Patrizia Vici, Marcello Maugeri-Saccà, Saverio Stranges, Nancy Santesso, Luciano Mariani, Antonio Giordano, Domenico Sergi, Laura Pizzuti, Luigi Di Lauro, Maurizio Montella, Anna Crispo, Marcella Mottolese, Maddalena Barba

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

In recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D supplementation on breast cancer incidence, we conducted a systematic review and meta-analysis of randomized controlled trials comparing vitamin D with placebo or no treatment. We used OVID to search MEDLINE (R), EMBASE and CENTRAL until April 2012. We screened the reference lists of included studies and used the "Related Article" feature in PubMed to identify additional articles. No language restrictions were applied. Two reviewers independently extracted data on methodological quality, participants, intervention, comparison and outcomes. Risk Ratios and 95% Confident Intervals for breast cancer were pooled using a random-effects model. Heterogeneity was assessed using the I2 test. In sensitivity analysis, we assessed the impact of vitamin D dosage and mode of administration on treatment effects. Only two randomized controlled trials fulfilled the pre-set inclusion criteria. The pooled analysis included 5372 postmenopausal women. Overall, Risk Ratios and 95% Confident Intervals were 1.11 and 0.74-1.68. We found no evidence of heterogeneity. Neither vitamin D dosage nor mode of administration significantly affected breast cancer risk. However, treatment efficacy was somewhat greater when vitamin D was administered at the highest dosage and in combination with calcium (Risk Ratio 0.58, 95% Confident Interval 0.23-1.47 and Risk Ratio 0.93, 95% Confident Interval 0.54-1.60, respectively). In conclusions, vitamin D use seems not to be associated with a reduced risk of breast cancer development in postmenopausal women. However, the available evidence is still limited and inadequate to draw firm conclusions. Study protocol code: FARM8L2B5L.

Original languageEnglish
Article numbere69269
JournalPLoS One
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 22 2013

Fingerprint

randomized clinical trials
systematic review
vitamin D
meta-analysis
Vitamin D
breast neoplasms
Meta-Analysis
Randomized Controlled Trials
Breast Neoplasms
relative risk
Odds Ratio
dosage
PubMed
MEDLINE
Sensitivity analysis
placebos
Language
Placebos
Calcium
calcium

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Vitamin D Supplementation and Breast Cancer Prevention : A Systematic Review and Meta-Analysis of Randomized Clinical Trials. / Sperati, Francesca; Vici, Patrizia; Maugeri-Saccà, Marcello; Stranges, Saverio; Santesso, Nancy; Mariani, Luciano; Giordano, Antonio; Sergi, Domenico; Pizzuti, Laura; Di Lauro, Luigi; Montella, Maurizio; Crispo, Anna; Mottolese, Marcella; Barba, Maddalena.

In: PLoS One, Vol. 8, No. 7, e69269, 22.07.2013.

Research output: Contribution to journalArticle

Sperati, F, Vici, P, Maugeri-Saccà, M, Stranges, S, Santesso, N, Mariani, L, Giordano, A, Sergi, D, Pizzuti, L, Di Lauro, L, Montella, M, Crispo, A, Mottolese, M & Barba, M 2013, 'Vitamin D Supplementation and Breast Cancer Prevention: A Systematic Review and Meta-Analysis of Randomized Clinical Trials', PLoS One, vol. 8, no. 7, e69269. https://doi.org/10.1371/journal.pone.0069269
Sperati, Francesca ; Vici, Patrizia ; Maugeri-Saccà, Marcello ; Stranges, Saverio ; Santesso, Nancy ; Mariani, Luciano ; Giordano, Antonio ; Sergi, Domenico ; Pizzuti, Laura ; Di Lauro, Luigi ; Montella, Maurizio ; Crispo, Anna ; Mottolese, Marcella ; Barba, Maddalena. / Vitamin D Supplementation and Breast Cancer Prevention : A Systematic Review and Meta-Analysis of Randomized Clinical Trials. In: PLoS One. 2013 ; Vol. 8, No. 7.
@article{dcf5593145284f54b0a899300d6586be,
title = "Vitamin D Supplementation and Breast Cancer Prevention: A Systematic Review and Meta-Analysis of Randomized Clinical Trials",
abstract = "In recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D supplementation on breast cancer incidence, we conducted a systematic review and meta-analysis of randomized controlled trials comparing vitamin D with placebo or no treatment. We used OVID to search MEDLINE (R), EMBASE and CENTRAL until April 2012. We screened the reference lists of included studies and used the {"}Related Article{"} feature in PubMed to identify additional articles. No language restrictions were applied. Two reviewers independently extracted data on methodological quality, participants, intervention, comparison and outcomes. Risk Ratios and 95{\%} Confident Intervals for breast cancer were pooled using a random-effects model. Heterogeneity was assessed using the I2 test. In sensitivity analysis, we assessed the impact of vitamin D dosage and mode of administration on treatment effects. Only two randomized controlled trials fulfilled the pre-set inclusion criteria. The pooled analysis included 5372 postmenopausal women. Overall, Risk Ratios and 95{\%} Confident Intervals were 1.11 and 0.74-1.68. We found no evidence of heterogeneity. Neither vitamin D dosage nor mode of administration significantly affected breast cancer risk. However, treatment efficacy was somewhat greater when vitamin D was administered at the highest dosage and in combination with calcium (Risk Ratio 0.58, 95{\%} Confident Interval 0.23-1.47 and Risk Ratio 0.93, 95{\%} Confident Interval 0.54-1.60, respectively). In conclusions, vitamin D use seems not to be associated with a reduced risk of breast cancer development in postmenopausal women. However, the available evidence is still limited and inadequate to draw firm conclusions. Study protocol code: FARM8L2B5L.",
author = "Francesca Sperati and Patrizia Vici and Marcello Maugeri-Sacc{\`a} and Saverio Stranges and Nancy Santesso and Luciano Mariani and Antonio Giordano and Domenico Sergi and Laura Pizzuti and {Di Lauro}, Luigi and Maurizio Montella and Anna Crispo and Marcella Mottolese and Maddalena Barba",
year = "2013",
month = "7",
day = "22",
doi = "10.1371/journal.pone.0069269",
language = "English",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

TY - JOUR

T1 - Vitamin D Supplementation and Breast Cancer Prevention

T2 - A Systematic Review and Meta-Analysis of Randomized Clinical Trials

AU - Sperati, Francesca

AU - Vici, Patrizia

AU - Maugeri-Saccà, Marcello

AU - Stranges, Saverio

AU - Santesso, Nancy

AU - Mariani, Luciano

AU - Giordano, Antonio

AU - Sergi, Domenico

AU - Pizzuti, Laura

AU - Di Lauro, Luigi

AU - Montella, Maurizio

AU - Crispo, Anna

AU - Mottolese, Marcella

AU - Barba, Maddalena

PY - 2013/7/22

Y1 - 2013/7/22

N2 - In recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D supplementation on breast cancer incidence, we conducted a systematic review and meta-analysis of randomized controlled trials comparing vitamin D with placebo or no treatment. We used OVID to search MEDLINE (R), EMBASE and CENTRAL until April 2012. We screened the reference lists of included studies and used the "Related Article" feature in PubMed to identify additional articles. No language restrictions were applied. Two reviewers independently extracted data on methodological quality, participants, intervention, comparison and outcomes. Risk Ratios and 95% Confident Intervals for breast cancer were pooled using a random-effects model. Heterogeneity was assessed using the I2 test. In sensitivity analysis, we assessed the impact of vitamin D dosage and mode of administration on treatment effects. Only two randomized controlled trials fulfilled the pre-set inclusion criteria. The pooled analysis included 5372 postmenopausal women. Overall, Risk Ratios and 95% Confident Intervals were 1.11 and 0.74-1.68. We found no evidence of heterogeneity. Neither vitamin D dosage nor mode of administration significantly affected breast cancer risk. However, treatment efficacy was somewhat greater when vitamin D was administered at the highest dosage and in combination with calcium (Risk Ratio 0.58, 95% Confident Interval 0.23-1.47 and Risk Ratio 0.93, 95% Confident Interval 0.54-1.60, respectively). In conclusions, vitamin D use seems not to be associated with a reduced risk of breast cancer development in postmenopausal women. However, the available evidence is still limited and inadequate to draw firm conclusions. Study protocol code: FARM8L2B5L.

AB - In recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D supplementation on breast cancer incidence, we conducted a systematic review and meta-analysis of randomized controlled trials comparing vitamin D with placebo or no treatment. We used OVID to search MEDLINE (R), EMBASE and CENTRAL until April 2012. We screened the reference lists of included studies and used the "Related Article" feature in PubMed to identify additional articles. No language restrictions were applied. Two reviewers independently extracted data on methodological quality, participants, intervention, comparison and outcomes. Risk Ratios and 95% Confident Intervals for breast cancer were pooled using a random-effects model. Heterogeneity was assessed using the I2 test. In sensitivity analysis, we assessed the impact of vitamin D dosage and mode of administration on treatment effects. Only two randomized controlled trials fulfilled the pre-set inclusion criteria. The pooled analysis included 5372 postmenopausal women. Overall, Risk Ratios and 95% Confident Intervals were 1.11 and 0.74-1.68. We found no evidence of heterogeneity. Neither vitamin D dosage nor mode of administration significantly affected breast cancer risk. However, treatment efficacy was somewhat greater when vitamin D was administered at the highest dosage and in combination with calcium (Risk Ratio 0.58, 95% Confident Interval 0.23-1.47 and Risk Ratio 0.93, 95% Confident Interval 0.54-1.60, respectively). In conclusions, vitamin D use seems not to be associated with a reduced risk of breast cancer development in postmenopausal women. However, the available evidence is still limited and inadequate to draw firm conclusions. Study protocol code: FARM8L2B5L.

UR - http://www.scopus.com/inward/record.url?scp=84880669599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880669599&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0069269

DO - 10.1371/journal.pone.0069269

M3 - Article

C2 - 23894438

AN - SCOPUS:84880669599

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 7

M1 - e69269

ER -