Vitamin E and nicotinamide have similar effects in maintaining residual beta cell function in recent onset insulin-dependent diabetes (the IMDIAB IV study)

Paolo Pozzilli, Natalia Visalli, Maria Gisella Cavallo, Alberto Signore, Marco G. Baroni, Raffaella Buzzetti, Elvira Fioriti, Chiara Mesturino, Rossana Fiori, Alfredo Romiti, Claudio Giovannini, Lucio Lucentini, Maria Cristina Matteoli, Antonio Crinò, Carlo Teodonio, Francesco Paci, Rita Amoretti, Luigi Pisano, Maria Teresa Suraci, Giuseppe MultariMariantonietta Suppa, Nicoletta Sulli, Giancarlo De Mattia, Maria Rita Cassone Faldetta, Brunetto Boscherini, Stefania Stoduto, Maria Teresa Fonte, Maria Luisa Manca Bitti, Giovanni Marietti, Federica Ferrazzoli, Aldo V. Greco, Giovanni Ghirlanda

Research output: Contribution to journalArticle

Abstract

Objective: Protection of residual beta cell function at the time of diagnosis of insulin-dependent diabetes mellitus (IDDM) by intensive insulin therapy and the addition of nicotinamide (NA) has been established. The objective of this study was to evaluate the effect of a free oxygen radical scavenger such as vitamin E (Vit E) on residual beta cell function and parameters of metabolic control in patients with recent onset IDDM undergoing intensive insulin therapy. Design: The effect of Vit E was compared with that of NA (control group) in a randomized multicentre trial. Methods: Eighty- four IDDM patients between 5 and 35 years of age (mean age 15.8± 8.4 (S.D.) years) entered a one year prospective study. One group of patients (n=42) was treated with Vit E (15 mg/kg body weight/day) for one year; the other group (n=42) received NA for one year (25mg/kg body weight/day). All patients were under intensive insulin therapy with three to four injections a day. Basal and stimulated (1 mg i.v. glucagon) C-peptide secretion, glycosylated haemoglobin and insulin dose were evaluated at diagnosis and at three- monthly intervals up to one year. Results: Preservation and slight increase of C-peptide levels at one year compared with diagnosis were obtained in the two treated patient groups. No statistically significant differences were observed in basal or stimulated C-peptide levels between the two groups of patients for up to one year after diagnosis. Glycosylated haemoglobin and insulin dose were also similar between the two groups; however patients receiving Vit E under the age of 15 years required significantly more insulin than NAtreated patients one year after diagnosis (P

Original languageEnglish
Pages (from-to)234-239
Number of pages6
JournalEuropean Journal of Endocrinology
Volume137
Issue number3
DOIs
Publication statusPublished - Sep 1997

ASJC Scopus subject areas

  • Endocrinology

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    Pozzilli, P., Visalli, N., Cavallo, M. G., Signore, A., Baroni, M. G., Buzzetti, R., Fioriti, E., Mesturino, C., Fiori, R., Romiti, A., Giovannini, C., Lucentini, L., Matteoli, M. C., Crinò, A., Teodonio, C., Paci, F., Amoretti, R., Pisano, L., Suraci, M. T., ... Ghirlanda, G. (1997). Vitamin E and nicotinamide have similar effects in maintaining residual beta cell function in recent onset insulin-dependent diabetes (the IMDIAB IV study). European Journal of Endocrinology, 137(3), 234-239. https://doi.org/10.1530/eje.0.1370234