Vitamin e intake from natural sources and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium

V. Edefonti, M. Hashibe, M. Parpinel, M. Ferraroni, F. Turati, D. Serraino, K. Matsuo, A. F. Olshan, J. P. Zevallos, D. M. Winn, K. Moysich, Z. F. Zhang, H. Morgenstern, F. Levi, K. Kelsey, M. McClean, C. Bosetti, S. Schantz, G. P. Yu, P. BoffettaS. C. Chuang, Y. C. A Lee, C. La Vecchia, A. Decarli

Research output: Contribution to journalArticlepeer-review

Abstract

Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited.Methods:We used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of nonalcohol energy-adjusted vitamin E intake.Results:Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category=0.59, 95% CI: 0.49-0.71; P for trend

Original languageEnglish
Pages (from-to)182-192
Number of pages11
JournalBritish Journal of Cancer
Volume113
Issue number1
DOIs
Publication statusPublished - Jun 30 2015

Keywords

  • Head and neck cancer
  • INHANCE
  • laryngeal cancer
  • oral and pharyngeal cancer
  • vitamin E

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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