Background Few studies have investigated the effect of Vitamin E in reducing the cisplatin (CDDP)-induced ototoxicity. This study evaluated Vitamin E supplementation as a protecting agent against CDDP-induced ototoxicity. Methods Patients who started CDDP were randomly assigned to receive Vitamin E supplementation at 400 mg per day (group 1) or placebo (group 2). Audiograms and evoked brainstem responses were obtained at baseline, and after 1, 2, and 3 months. Results Twenty-three patients affected by solid malignancies were enrolled (13 in group 1 and 10 in group 2). At 1 month, a significant hearing loss in group 2 at both 2000 HZ (right ear: p =.05; left ear: p =.04) and 8000 HZ (right ear: p =.04; left ear: p =.03) was detected when compared to baseline values. Audiograms did not show significant changes. At 1 month, evoked brainstem responses remained unchanged in both arms without significant differences between groups. Conclusion These preliminary findings confirm the neuroprotective properties of Vitamin E against the CDDP-induced ototoxicity.
- Vitamin E
ASJC Scopus subject areas