Vitamin K deficiency

a case report and review of current guidelines

Maria Rosaria Marchili, Elisa Santoro, Alessandra Marchesi, Simona Bianchi, Lelia Rotondi Aufiero, Alberto Villani

Research output: Contribution to journalReview article

Abstract

BACKGROUND: Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB).

CASE PRESENTATION: We present the case of a 2 months and 20 days Caucasian male, presented for bleeding from the injections sites of vaccines. At birth oral vitamin K prophylaxis was administered. Neonatal period was normal. He was exclusively breastfed and received a daily oral supplementation with 25 μg of vitamin K. A late onset vitamin K deficiency bleeding was suspected. Intravenous Vitamin K was administered with complete recovery.

CONCLUSIONS: Nevertheless the oral prophylaxis, our case developed a VKDB: it is necessary to revise the current guidelines in order to standardize timing and dosage in different clinical conditions.

Original languageEnglish
Pages (from-to)36
Number of pages5
JournalItalian Journal of Pediatrics
Volume44
Issue number1
DOIs
Publication statusPublished - Mar 14 2018

Fingerprint

Vitamin K Deficiency
Vitamin K Deficiency Bleeding
Vitamin K
Guidelines
Factor VII
Protein S
Prothrombin
Protein C
Vitamins
Vaccines
Fats
Parturition
Hemorrhage
Injections

Keywords

  • Administration, Oral
  • Antifibrinolytic Agents/administration & dosage
  • Hemorrhage/etiology
  • Humans
  • Infant
  • Male
  • Practice Guidelines as Topic
  • Vitamin K/administration & dosage
  • Vitamin K Deficiency/complications

Cite this

Vitamin K deficiency : a case report and review of current guidelines. / Marchili, Maria Rosaria; Santoro, Elisa; Marchesi, Alessandra; Bianchi, Simona; Rotondi Aufiero, Lelia; Villani, Alberto.

In: Italian Journal of Pediatrics, Vol. 44, No. 1, 14.03.2018, p. 36.

Research output: Contribution to journalReview article

Marchili, Maria Rosaria ; Santoro, Elisa ; Marchesi, Alessandra ; Bianchi, Simona ; Rotondi Aufiero, Lelia ; Villani, Alberto. / Vitamin K deficiency : a case report and review of current guidelines. In: Italian Journal of Pediatrics. 2018 ; Vol. 44, No. 1. pp. 36.
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T2 - a case report and review of current guidelines

AU - Marchili, Maria Rosaria

AU - Santoro, Elisa

AU - Marchesi, Alessandra

AU - Bianchi, Simona

AU - Rotondi Aufiero, Lelia

AU - Villani, Alberto

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N2 - BACKGROUND: Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB).CASE PRESENTATION: We present the case of a 2 months and 20 days Caucasian male, presented for bleeding from the injections sites of vaccines. At birth oral vitamin K prophylaxis was administered. Neonatal period was normal. He was exclusively breastfed and received a daily oral supplementation with 25 μg of vitamin K. A late onset vitamin K deficiency bleeding was suspected. Intravenous Vitamin K was administered with complete recovery.CONCLUSIONS: Nevertheless the oral prophylaxis, our case developed a VKDB: it is necessary to revise the current guidelines in order to standardize timing and dosage in different clinical conditions.

AB - BACKGROUND: Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB).CASE PRESENTATION: We present the case of a 2 months and 20 days Caucasian male, presented for bleeding from the injections sites of vaccines. At birth oral vitamin K prophylaxis was administered. Neonatal period was normal. He was exclusively breastfed and received a daily oral supplementation with 25 μg of vitamin K. A late onset vitamin K deficiency bleeding was suspected. Intravenous Vitamin K was administered with complete recovery.CONCLUSIONS: Nevertheless the oral prophylaxis, our case developed a VKDB: it is necessary to revise the current guidelines in order to standardize timing and dosage in different clinical conditions.

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