Vitamin K deficiency: a case report and review of current guidelines

Maria Rosaria Marchili, Elisa Santoro, Alessandra Marchesi, Simona Bianchi, Lelia Rotondi Aufiero, Alberto Villani

Research output: Contribution to journalReview articlepeer-review


BACKGROUND: Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB).

CASE PRESENTATION: We present the case of a 2 months and 20 days Caucasian male, presented for bleeding from the injections sites of vaccines. At birth oral vitamin K prophylaxis was administered. Neonatal period was normal. He was exclusively breastfed and received a daily oral supplementation with 25 μg of vitamin K. A late onset vitamin K deficiency bleeding was suspected. Intravenous Vitamin K was administered with complete recovery.

CONCLUSIONS: Nevertheless the oral prophylaxis, our case developed a VKDB: it is necessary to revise the current guidelines in order to standardize timing and dosage in different clinical conditions.

Original languageEnglish
Pages (from-to)36
Number of pages5
JournalItalian Journal of Pediatrics
Issue number1
Publication statusPublished - Mar 14 2018


  • Administration, Oral
  • Antifibrinolytic Agents/administration & dosage
  • Hemorrhage/etiology
  • Humans
  • Infant
  • Male
  • Practice Guidelines as Topic
  • Vitamin K/administration & dosage
  • Vitamin K Deficiency/complications


Dive into the research topics of 'Vitamin K deficiency: a case report and review of current guidelines'. Together they form a unique fingerprint.

Cite this