Abstract
Anticoagulants of the coumarin type have long been reported to inhibit metastasis growth in experimental animals; however, the mechanisms of such effects has not been clarified. Systemic anticoagulation per se does not appear to account completely for such metastasis growth depression. More recent information gathered on a cell procoagulant activity, which is vitamin K-dependent, could probably supply a fresh insight into this problem. Indeed, vitamin K deficiency induced either dietarily or pharmacologically by warfarin, does inhibit the activity of a cysteine protease with direct factor-X-activating properties. This protease is only present in warfarin-sensitive tumors. The correlation of this activity with cancer cell invasiveness is supported by experimental data in metastatic variants and, lately, also by the observation of markedly higher cancer procoagulant activity in extracts from metastases than from primary human melanomas.
| Original language | English |
|---|---|
| Pages (from-to) | 288-294 |
| Number of pages | 7 |
| Journal | Pathophysiology of Haemostasis and Thrombosis |
| Volume | 16 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - 1986 |
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Keywords
- Cancer procoagulant
- Metastases
- Vitamin K
- Warfarin
ASJC Scopus subject areas
- Hematology
- Physiology (medical)
Cite this
Vitamin K-dependent procoagulant in cancer cells : A potential target for the antimetastatic effect of warfarin? / Donati, Maria Benedetta; Roncaglioni, Maria Carla; Falanga, Anna; Casali, Bruno; Semeraro, Nicola.
In: Pathophysiology of Haemostasis and Thrombosis, Vol. 16, No. 3-4, 1986, p. 288-294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin K-dependent procoagulant in cancer cells
T2 - A potential target for the antimetastatic effect of warfarin?
AU - Donati, Maria Benedetta
AU - Roncaglioni, Maria Carla
AU - Falanga, Anna
AU - Casali, Bruno
AU - Semeraro, Nicola
PY - 1986
Y1 - 1986
N2 - Anticoagulants of the coumarin type have long been reported to inhibit metastasis growth in experimental animals; however, the mechanisms of such effects has not been clarified. Systemic anticoagulation per se does not appear to account completely for such metastasis growth depression. More recent information gathered on a cell procoagulant activity, which is vitamin K-dependent, could probably supply a fresh insight into this problem. Indeed, vitamin K deficiency induced either dietarily or pharmacologically by warfarin, does inhibit the activity of a cysteine protease with direct factor-X-activating properties. This protease is only present in warfarin-sensitive tumors. The correlation of this activity with cancer cell invasiveness is supported by experimental data in metastatic variants and, lately, also by the observation of markedly higher cancer procoagulant activity in extracts from metastases than from primary human melanomas.
AB - Anticoagulants of the coumarin type have long been reported to inhibit metastasis growth in experimental animals; however, the mechanisms of such effects has not been clarified. Systemic anticoagulation per se does not appear to account completely for such metastasis growth depression. More recent information gathered on a cell procoagulant activity, which is vitamin K-dependent, could probably supply a fresh insight into this problem. Indeed, vitamin K deficiency induced either dietarily or pharmacologically by warfarin, does inhibit the activity of a cysteine protease with direct factor-X-activating properties. This protease is only present in warfarin-sensitive tumors. The correlation of this activity with cancer cell invasiveness is supported by experimental data in metastatic variants and, lately, also by the observation of markedly higher cancer procoagulant activity in extracts from metastases than from primary human melanomas.
KW - Cancer procoagulant
KW - Metastases
KW - Vitamin K
KW - Warfarin
UR - http://www.scopus.com/inward/record.url?scp=0022921435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022921435&partnerID=8YFLogxK
U2 - 10.1159/000215300
DO - 10.1159/000215300
M3 - Article
C2 - 3530903
AN - SCOPUS:0022921435
VL - 16
SP - 288
EP - 294
JO - Pathophysiology of Haemostasis and Thrombosis
JF - Pathophysiology of Haemostasis and Thrombosis
SN - 1424-8832
IS - 3-4
ER -