Vitamin K-dependent procoagulant in cancer cells: A potential target for the antimetastatic effect of warfarin?

Maria Benedetta Donati, Maria Carla Roncaglioni, Anna Falanga, Bruno Casali, Nicola Semeraro

Research output: Contribution to journalArticlepeer-review

Abstract

Anticoagulants of the coumarin type have long been reported to inhibit metastasis growth in experimental animals; however, the mechanisms of such effects has not been clarified. Systemic anticoagulation per se does not appear to account completely for such metastasis growth depression. More recent information gathered on a cell procoagulant activity, which is vitamin K-dependent, could probably supply a fresh insight into this problem. Indeed, vitamin K deficiency induced either dietarily or pharmacologically by warfarin, does inhibit the activity of a cysteine protease with direct factor-X-activating properties. This protease is only present in warfarin-sensitive tumors. The correlation of this activity with cancer cell invasiveness is supported by experimental data in metastatic variants and, lately, also by the observation of markedly higher cancer procoagulant activity in extracts from metastases than from primary human melanomas.

Original languageEnglish
Pages (from-to)288-294
Number of pages7
JournalPathophysiology of Haemostasis and Thrombosis
Volume16
Issue number3-4
DOIs
Publication statusPublished - 1986

Keywords

  • Cancer procoagulant
  • Metastases
  • Vitamin K
  • Warfarin

ASJC Scopus subject areas

  • Hematology
  • Physiology (medical)

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