Vitamin K deficiency can account for serious bleeding in the neonatal period. Oral and intramuscular prophylaxis at birth can prevent classical vitamin K bleeding (VKDB); however the efficacy on late VKDB is controversial. Oral phytomenadione prophylaxis given as single dose at birth is less effective than intramuscular administration. Multiple oral doses could be effective, but there are no uniform recommendations regarding the need of further supplementation. At this regard, a bibliographic search in MEDLINE was performed (using Clinical Queries mask) and an observational study concerning weekly oral vitamin K prophylaxis was found and evaluated. No cases of VKDB were revealed in 396,000 physiologic newborns receiving oral phytomenadione 2 mg at birth, followed by 1 mg weekly until 3 months of age. These results suggest that a weekly oral prophylaxis could be a cost effective strategy in preventing late VKDB.
|Translated title of the contribution||Vitamin K prophylaxis in the neonatal period: Evidence and controversies|
|Title of host publication||Quaderni ACP|
|Number of pages||3|
|Publication status||Published - Jan 2005|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health