Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition

Simone J P M Eussen, Stein Emil Vollset, Steinar Hustad, Øivind Midttun, Klaus Meyer, Åse Fredriksen, Per Magne Ueland, Mazda Jenab, Nadia Slimani, Pietro Ferrari, Antonio Agudo, Núria Sala, Gabriel Capellá, Giuseppe Del Giudice, Domenico Palli, Heiner Boeing, Cornelia Weikert, H. Bas Bueno-de-Mesquita, Frederike L. Büchner, Fátima CarneiroFranco Berrino, Paolo Vineis, Rosario Tumino, Salvatore Panico, Göran Berglund, Jonas Manjer, Roger Stenling, Göran Hallmans, Carmen Martínez, Larraitz Arrizola, Aurelio Barricarte, Carmen Navarro, Laudina Rodriguez, Sheila Bingham, Jakob Linseisen, Rudolf Kaaks, Kim Overvad, Anne Tjønneland, Petra H M Peeters, Mattijs E. Numans, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Sophie Morois, Antonia Trichopoulou, Eiliv Lund, Mario Plebani, Elio Riboli, Carlos A. González

Research output: Contribution to journalArticlepeer-review

Abstract

B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin B2 status, whereas the sum of pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for GC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, Ptrend) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93,

Original languageEnglish
Pages (from-to)28-38
Number of pages11
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2010

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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