Vitiligo is associated with a significant increase in HLA-A30, Cw6 AND DQw3 and a decrease in C4AQ0 in Northern Italian patients

Giovanni Orecchia, L. Perfetti, P. Malagolt, F. Borghini, Y. Kipervarg

Research output: Contribution to journalArticle

Abstract

HLA polymorphisms of class I (HLA-A, B, C) of class II (HLA-DR, DO) and of class III (C4A, C4B, BF) were investigated in 93 Northern Italian patients affected with vitiligo and in 388 controls. Vitiligo patients had significant increases in HLA-A30 (corrected p, pc = 0.0144). Cw6 (pc=0.0189), DQw3 (pcc = 0.003). Nonfamilial vitiligo is marked by increases in HLA-A30 and DQw3. Extensive vitiligo is marked by increases in HLA-A30 and Cw6. These findings suggest that immu- nogenetic mechanisms may be responsible for vitiligo and that unique HLA phenotypes may influence the expression of vitiligo in this population.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalDermatology
Volume185
Issue number2
DOIs
Publication statusPublished - 1992

Keywords

  • Complement
  • Human leukocyte antigen
  • Major histocompatibility complex
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology

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