HLA polymorphisms of class I (HLA-A, B, C) of class II (HLA-DR, DO) and of class III (C4A, C4B, BF) were investigated in 93 Northern Italian patients affected with vitiligo and in 388 controls. Vitiligo patients had significant increases in HLA-A30 (corrected p, pc = 0.0144). Cw6 (pc=0.0189), DQw3 (pcc = 0.003). Nonfamilial vitiligo is marked by increases in HLA-A30 and DQw3. Extensive vitiligo is marked by increases in HLA-A30 and Cw6. These findings suggest that immu- nogenetic mechanisms may be responsible for vitiligo and that unique HLA phenotypes may influence the expression of vitiligo in this population.
- Human leukocyte antigen
- Major histocompatibility complex
ASJC Scopus subject areas