Vitiligo: Pathogenetic hypotheses and targets for current therapies

Liliana Guerra, Elena Dellambra, Serena Brescia, Desanka Raskovic

Research output: Contribution to journalArticlepeer-review

Abstract

Vitiligo is a multifactorial disorder characterized by the appearance of white maculae that may spread over the entire body skin. Depigmentation arises from the loss of functioning melanocytes. Non segmental vitiligo (NSV) is the most common form of the disease: it is usually progressive and may be associated with familiarity and autoimmunity. Segmental vitiligo (SV) frequently stabilizes few years after its onset. Vitiligo etiology involves multiple pathogenetic factors, most of them working in concert. Impaired antioxidative defences lead to accumulation of reactive oxygen species (ROS), which affect melanocytes. Mitochondrial membrane lipid peroxidation may participate to ROS overproduction. A temporal sequence may connect oxidative stress and autoimmunity. Overall, a genetic predisposition renders vitiligo melanocytes more susceptible to precipitating factors than normal healthy melanocytes. The definition of isolated or superimposed manifestations of polygenic skin disorders has been proposed for SV and SV-NSV association. Keratinocytes and melanocytes are both affected and apoptosis, ageing or melanocythorragy are the ultimate effects of the complex deregulation in vitiligo skin. Pathogenetic therapies mainly act by inducing immunosuppression and stimulation of melanocyte proliferation and migration. Here the most popular hypotheses for the pathogenesis of vitiligo are summarized. Fundamental cellular, biochemical and molecular alterations accounting for melanocyte destruction in vitiligo are also described. Last, pathogenetic approaches in the treatment of such a complex disease are discussed, with particular consideration on the cellular and molecular targets of the current therapies.

Original languageEnglish
Pages (from-to)451-467
Number of pages17
JournalCurrent Drug Metabolism
Volume11
Issue number5
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Antioxidants
  • Apoptosis
  • Autoimmunity
  • Genetic
  • Immunomodulators
  • Melanocytorrhagy
  • Oxidative stress
  • Vitiligo

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Medicine(all)

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