Vitreomacular traction syndrome: A comparison of treatment with intravitreal plasmin enzyme vs spontaneous vitreous separation without treatment

M. Codenotti, G. Maestranzi, U. De Benedetto, G. Querques, P. Della Valle, L. Iuliano, G. Fogliato, A. D'Angelo, F. Bandello

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose To evaluate the effects of intravitreal autologous plasmin enzyme (APE) in patients with focal vitreomacular traction (VMT). Methods APE was obtained by incubation of patient-derived purified plasminogen with streptokinase, and intravitreally injected 5-12 days later. Twenty-four hours after injection, in case of incomplete VMT release, a pars plana vitrectomy was performed. The hyaloid internal limiting membrane adherence and removal of the posterior hyaloid were intraoperatively evaluated. Results Thirteen patients were recruited. During preparation of APE, five patients had spontaneous release of VMT. Eight patients received APE injection (2 IU). In five patients, spontaneous resolution of VMT occurred before APE administration. Twenty-four hours after injection, persistence of VMT was detected in all the eight treated patients. Best-corrected visual acuity was 0.51±0.37 LogMAR at baseline, improving to 0.23±0.14 LogMAR at 6 months (P=0.002). Foveal thickness was 464±180 μm at baseline, reducing to 246±59 μm at 6 months (P

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalEye (London, England)
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • autologous plasmin
  • enzymatic vitreolysis
  • vitrectomy
  • vitreomacular traction syndrome

ASJC Scopus subject areas

  • Ophthalmology

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