VMCP chemotherapy with or without interferon-alpha-2 in newly diagnosed patients with multiple myeloma

Peter Preis; W. Scheithauer; E. Fritz; C. Zielinski; I. Kuehrer; A. Cortelezzi; E. Polli; L. Raldini; R. Pirker; A. Kriegisch; H. Ludwig

doi:10.1159/000216593

VMCP chemotherapy with or without interferon-alpha-2 in newly diagnosed patients with multiple myeloma

Peter Preis, W. Scheithauer, E. Fritz, C. Zielinski, I. Kuehrer, A. Cortelezzi, E. Polli, L. Raldini, R. Pirker, A. Kriegisch, H. Ludwig

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Fifty-two previously untreated patients with multiple myeloma were randomized to either a combination of recombinant interferon (rIFN) alpha-2 and chemotherapy or chemotherapy alone. Patients were treated with vincristine, melphalan, cyclophosphamide and prednisolone every 4-6 weeks. In the combined treatment arm rIFN was administered concurrently with chemotherapy as well as during chemotherapy free intervals. The combined regimen effected 17/21 (80.9%) responses as compared to 19/27 (70.4%) responses in VMCP treated patients. Addition of rIFN to chemotherapy did not enhance hematologic toxicity. These findings suggest a somewhat higher rate of objective response in the VPMC + rIFN group, although a significant improvement in median survival by adding rIFN to conventional first line polychemotherapy in myeloma patients has not yet been achieved.

Original language	English
Pages (from-to)	27-29
Number of pages	3
Journal	Oncology Research and Treatment
Volume	12
Issue number	1
DOIs	https://doi.org/10.1159/000216593
Publication status	Published - 1989

Keywords

Combinations treatment
Interferon-alpha-2
Multiples Myeloma

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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VMCP chemotherapy with or without interferon-alpha-2 in newly diagnosed patients with multiple myeloma. / Preis, Peter; Scheithauer, W.; Fritz, E.; Zielinski, C.; Kuehrer, I.; Cortelezzi, A.; Polli, E.; Raldini, L.; Pirker, R.; Kriegisch, A.; Ludwig, H.

In: Oncology Research and Treatment, Vol. 12, No. 1, 1989, p. 27-29.

Research output: Contribution to journal › Article › peer-review

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AU - Cortelezzi, A.

AU - Polli, E.

AU - Raldini, L.

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AU - Kriegisch, A.

AU - Ludwig, H.

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