VNCOP-B plus rituximab in the treatment of diffuse large B-cell lymphoma in the elderly

Mariapaola Fina, Monica Tani, Vittorio Stefoni, Gerardo Musuraca, Enrica Marchi, Cinzia Pellegrini, Lapo Alinari, Enrico Derenzini, Francesco Bacci, Stefano Pileri, Michele Baccarani, Pier Luigi Zinzani

Research output: Contribution to journalArticle

Abstract

The conventional treatment included CHOP and several age-adapted regimens, from first to third generation, designed and tested for their feasibility and efficacy in elderly patients. Recently, some trials demonstrated that CHOP-rituximab was superior to CHOP alone. Between February 2003 and November 2005, 24 untreated patients 60 years and older with DLBCL were treated with a combination therapy including cyclophosphamide, mitoxantrone, vincristine, etoposide, bleomycin, and prednisone (VNCOP-B) plus four rituximab administrations. Nineteen of the 24 patients (80%) obtained a CR, four achieved a PR, and the remaining patient had a disease progression. The overall response rate was 96%. Sixteen of the 19 complete responders remain in continuous CR at a median of 24 months (range 12-42). Three CRs relapsed within 12 months from the completion of treatment. Clinical and hematological toxicity was moderate. This regimen was effective in inducing a good remission rate with moderate toxic effects in elderly DLBCL patients.

Original languageEnglish
Pages (from-to)2167-2171
Number of pages5
JournalLeukemia and Lymphoma
Volume48
Issue number11
DOIs
Publication statusPublished - Nov 2007

Keywords

  • DLBCL
  • Elderly
  • VNCOP-B plus rituximab

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Fina, M., Tani, M., Stefoni, V., Musuraca, G., Marchi, E., Pellegrini, C., Alinari, L., Derenzini, E., Bacci, F., Pileri, S., Baccarani, M., & Zinzani, P. L. (2007). VNCOP-B plus rituximab in the treatment of diffuse large B-cell lymphoma in the elderly. Leukemia and Lymphoma, 48(11), 2167-2171. https://doi.org/10.1080/10428190701642102