Voltage-dependent cationic channels formed by a cytolytic toxin produced by Gardnerella vaginalis

Oscar Moran, Olga Zegarra-Moran, Caterina Virginio, Giandomenico Rottini

Research output: Contribution to journalArticle

Abstract

A cytolytic toxin produced by G. vaginalis was incorporated in artificial membranes and giant liposomes. The toxin formed ionic channels when incorporated in lipid bilayers. The electrical properties of such channels were studied. Current records revealed a unitary conductance of 126 pS (in symmetrical 150 mM KCl). The open state probability of the cytolysin formed channels was a function of the applied membrane potential. The permeability ratio of cations to anions was estimated to be 6.5.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalFEBS Letters
Volume283
Issue number2
DOIs
Publication statusPublished - Jun 3 1991

Keywords

  • Cytolytic toxin
  • Gardnerella vaginalis
  • Ionic channel
  • Patch clamp

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Genetics
  • Structural Biology

Fingerprint Dive into the research topics of 'Voltage-dependent cationic channels formed by a cytolytic toxin produced by Gardnerella vaginalis'. Together they form a unique fingerprint.

  • Cite this