Voltage-Operated Calcium Channel Heterogeneity in Pancreatic β Cells: Physiopathological Implications

E. Sher, F. Giovannini, A. Codignola, M. Passafaro, P. Giorgi-Rossi, S. Volsen, P. Craig, A. Davalli, P. Carrera

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Voltage-operated calcium channels play crucial roles in stimulus-secretion coupling in pancreatic β cells. A growing body of evidence indicates that these channels in β cells are heterogeneous. In particular, not all the high-threshold calcium channels expressed belong to the best known L-type. In rat insulinoma cells, for example, L, N, and P/Q-type channels are present, while in human β cells L-type and P/Q-type dominate. Where present, N-type and P/Q-type channels participate, alongside with the dominant L-type, in the control of sugar- or depolarization-induced hormone release. Distinct biophysical properties and selective modulation of the channel subtypes are likely to play important physiological roles. T-type channels are involved in beta cell apoptosis, while calcium channel autoantibodies recognizing high-threshold channels in β cells, have been described both in neurological and diabetic patients. Subtype-selective calcium channel drugs have the potential for being beneficial in beta cell pathological states.

Original languageEnglish
Pages (from-to)687-696
Number of pages10
JournalJournal of Bioenergetics and Biomembranes
Volume35
Issue number6
DOIs
Publication statusPublished - Dec 2003

Fingerprint

Calcium Channels
Insulinoma
Autoantibodies
Hormones
Apoptosis
Pharmaceutical Preparations

Keywords

  • β Cell
  • Calcium channel
  • Diabetes
  • Insulin release

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Cite this

Voltage-Operated Calcium Channel Heterogeneity in Pancreatic β Cells : Physiopathological Implications. / Sher, E.; Giovannini, F.; Codignola, A.; Passafaro, M.; Giorgi-Rossi, P.; Volsen, S.; Craig, P.; Davalli, A.; Carrera, P.

In: Journal of Bioenergetics and Biomembranes, Vol. 35, No. 6, 12.2003, p. 687-696.

Research output: Contribution to journalArticle

Sher, E, Giovannini, F, Codignola, A, Passafaro, M, Giorgi-Rossi, P, Volsen, S, Craig, P, Davalli, A & Carrera, P 2003, 'Voltage-Operated Calcium Channel Heterogeneity in Pancreatic β Cells: Physiopathological Implications', Journal of Bioenergetics and Biomembranes, vol. 35, no. 6, pp. 687-696. https://doi.org/10.1023/B:JOBB.0000008032.49504.48
Sher, E. ; Giovannini, F. ; Codignola, A. ; Passafaro, M. ; Giorgi-Rossi, P. ; Volsen, S. ; Craig, P. ; Davalli, A. ; Carrera, P. / Voltage-Operated Calcium Channel Heterogeneity in Pancreatic β Cells : Physiopathological Implications. In: Journal of Bioenergetics and Biomembranes. 2003 ; Vol. 35, No. 6. pp. 687-696.
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