Volumetric breast density and risk of advanced cancers after a negative screening episode: A cohort study

the DENSITY Working Group

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We evaluated the association between volumetric breast density (BD) and risk of advanced cancers after a negative screening episode. Methods: A cohort of 16,752 women aged 49-54 years at their first screening mammography in the Florence screening programme was followed for breast cancer (BC) incidence until the second screening round. Volumetric BD was measured using fully automated software. The cumulative incidence of advanced cancer after a negative screening episode (including stage II or more severe cancer during the screening interval - on average 28 months - and at the subsequent round) was calculated separately for Volpara density grade (VDG) categories. Results: BC incidence gradually increased with the increas in BD: 3.7‰, 5.1‰, 5.4‰ and 9.1‰ in the VDG categories 1-4, respectively (p trend < 0.001). The risk of advanced cancers after a negative screening episode was 1.0‰, 1.3‰, 1.1‰, and 4.2‰ (p trend = 0.003). The highest BD category, compared with the other three together, has double the invasive BC risk (RR = 2.0; 95% CI 1.5-2.8) and almost fourfold risk of advanced cancer (RR = 3.8; 95% CI 1.8-8.0). Conclusion: BD has a strong impact on the risk of advanced cancers after a negative screening episode, the best early surrogate of BC mortality. Therefore, our results suggest that screening effectiveness is quite different among BD categories.

Original languageEnglish
Article number95
JournalBreast Cancer Research
Volume20
Issue number1
DOIs
Publication statusPublished - Aug 9 2018

Fingerprint

Cohort Studies
Breast Neoplasms
Neoplasms
Incidence
Mammography
Early Detection of Cancer
Breast Density
Software
Mortality

Keywords

  • Advanced stage
  • Breast cancer
  • Breast density
  • Mammography sensitivity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Volumetric breast density and risk of advanced cancers after a negative screening episode : A cohort study. / the DENSITY Working Group.

In: Breast Cancer Research, Vol. 20, No. 1, 95, 09.08.2018.

Research output: Contribution to journalArticle

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title = "Volumetric breast density and risk of advanced cancers after a negative screening episode: A cohort study",
abstract = "Background: We evaluated the association between volumetric breast density (BD) and risk of advanced cancers after a negative screening episode. Methods: A cohort of 16,752 women aged 49-54 years at their first screening mammography in the Florence screening programme was followed for breast cancer (BC) incidence until the second screening round. Volumetric BD was measured using fully automated software. The cumulative incidence of advanced cancer after a negative screening episode (including stage II or more severe cancer during the screening interval - on average 28 months - and at the subsequent round) was calculated separately for Volpara density grade (VDG) categories. Results: BC incidence gradually increased with the increas in BD: 3.7‰, 5.1‰, 5.4‰ and 9.1‰ in the VDG categories 1-4, respectively (p trend < 0.001). The risk of advanced cancers after a negative screening episode was 1.0‰, 1.3‰, 1.1‰, and 4.2‰ (p trend = 0.003). The highest BD category, compared with the other three together, has double the invasive BC risk (RR = 2.0; 95{\%} CI 1.5-2.8) and almost fourfold risk of advanced cancer (RR = 3.8; 95{\%} CI 1.8-8.0). Conclusion: BD has a strong impact on the risk of advanced cancers after a negative screening episode, the best early surrogate of BC mortality. Therefore, our results suggest that screening effectiveness is quite different among BD categories.",
keywords = "Advanced stage, Breast cancer, Breast density, Mammography sensitivity",
author = "{the DENSITY Working Group} and D. Puliti and Marco Zappa and {Giorgi Rossi}, Paolo and Elena Pierpaoli and Gianfranco Manneschi and D. Ambrogetti and Leonardo Ventura and Paola Mantellini and P. Falini and G. Manneschi and D. Puliti and L. Ventura and M. Zappa and D. Ambrogetti and E. Carnesciali and V. Mazzalupo and P. Mantellini and B. Lazzari and E. Pierpaoli",
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T1 - Volumetric breast density and risk of advanced cancers after a negative screening episode

T2 - A cohort study

AU - the DENSITY Working Group

AU - Puliti, D.

AU - Zappa, Marco

AU - Giorgi Rossi, Paolo

AU - Pierpaoli, Elena

AU - Manneschi, Gianfranco

AU - Ambrogetti, D.

AU - Ventura, Leonardo

AU - Mantellini, Paola

AU - Falini, P.

AU - Manneschi, G.

AU - Puliti, D.

AU - Ventura, L.

AU - Zappa, M.

AU - Ambrogetti, D.

AU - Carnesciali, E.

AU - Mazzalupo, V.

AU - Mantellini, P.

AU - Lazzari, B.

AU - Pierpaoli, E.

PY - 2018/8/9

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N2 - Background: We evaluated the association between volumetric breast density (BD) and risk of advanced cancers after a negative screening episode. Methods: A cohort of 16,752 women aged 49-54 years at their first screening mammography in the Florence screening programme was followed for breast cancer (BC) incidence until the second screening round. Volumetric BD was measured using fully automated software. The cumulative incidence of advanced cancer after a negative screening episode (including stage II or more severe cancer during the screening interval - on average 28 months - and at the subsequent round) was calculated separately for Volpara density grade (VDG) categories. Results: BC incidence gradually increased with the increas in BD: 3.7‰, 5.1‰, 5.4‰ and 9.1‰ in the VDG categories 1-4, respectively (p trend < 0.001). The risk of advanced cancers after a negative screening episode was 1.0‰, 1.3‰, 1.1‰, and 4.2‰ (p trend = 0.003). The highest BD category, compared with the other three together, has double the invasive BC risk (RR = 2.0; 95% CI 1.5-2.8) and almost fourfold risk of advanced cancer (RR = 3.8; 95% CI 1.8-8.0). Conclusion: BD has a strong impact on the risk of advanced cancers after a negative screening episode, the best early surrogate of BC mortality. Therefore, our results suggest that screening effectiveness is quite different among BD categories.

AB - Background: We evaluated the association between volumetric breast density (BD) and risk of advanced cancers after a negative screening episode. Methods: A cohort of 16,752 women aged 49-54 years at their first screening mammography in the Florence screening programme was followed for breast cancer (BC) incidence until the second screening round. Volumetric BD was measured using fully automated software. The cumulative incidence of advanced cancer after a negative screening episode (including stage II or more severe cancer during the screening interval - on average 28 months - and at the subsequent round) was calculated separately for Volpara density grade (VDG) categories. Results: BC incidence gradually increased with the increas in BD: 3.7‰, 5.1‰, 5.4‰ and 9.1‰ in the VDG categories 1-4, respectively (p trend < 0.001). The risk of advanced cancers after a negative screening episode was 1.0‰, 1.3‰, 1.1‰, and 4.2‰ (p trend = 0.003). The highest BD category, compared with the other three together, has double the invasive BC risk (RR = 2.0; 95% CI 1.5-2.8) and almost fourfold risk of advanced cancer (RR = 3.8; 95% CI 1.8-8.0). Conclusion: BD has a strong impact on the risk of advanced cancers after a negative screening episode, the best early surrogate of BC mortality. Therefore, our results suggest that screening effectiveness is quite different among BD categories.

KW - Advanced stage

KW - Breast cancer

KW - Breast density

KW - Mammography sensitivity

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