TY - JOUR
T1 - Volumetric change of human papillomavirus-related neck lymph nodes before, during, and shortly after intensity-modulated radiation therapy
AU - Sanguineti, Giuseppe
AU - Ricchetti, Francesco
AU - Wu, Binbin
AU - Agrawal, Nishant
AU - Gourin, Christine
AU - Agbahiwe, Harold
AU - Marur, Shanthi
AU - Clemente, Stefania
AU - McNutt, Todd
AU - Forastiere, Arlene
PY - 2012/11
Y1 - 2012/11
N2 - Background. To assess volumetric changes of human papillomavirus (HPV)-related lymph nodes (LN) before, during, and after a course of intensity-modulated radiation therapy (IMRT) ± chemotherapy. Methods. Each "pathologic" LN (≥1 cm) was contoured on the available diagnostic/planning CTs before, during each week, and after treatment. Results. Seventy-nine LNs in 50 patients were identified. Beyond the first week of treatment, 3 patterns of LN change were recorded: consistently shrinking LN (n = 33; 41.8%), inconsistently shrinking LN with temporary enlargement limited to the first week (n = 14; 17.7%), or also during the subsequent weeks (n = 32; 40.5%). Nodal density at planning is highly predictive of group assignment, with a larger mean density for consistently over inconsistently shrinking LNs (p =.009). Also, this grouping predicts the response at the end of treatment. Conclusion. HPV-related LN behavior during IMRT is extremely variable but somewhat predictable on the basis of nodal density at planning.
AB - Background. To assess volumetric changes of human papillomavirus (HPV)-related lymph nodes (LN) before, during, and after a course of intensity-modulated radiation therapy (IMRT) ± chemotherapy. Methods. Each "pathologic" LN (≥1 cm) was contoured on the available diagnostic/planning CTs before, during each week, and after treatment. Results. Seventy-nine LNs in 50 patients were identified. Beyond the first week of treatment, 3 patterns of LN change were recorded: consistently shrinking LN (n = 33; 41.8%), inconsistently shrinking LN with temporary enlargement limited to the first week (n = 14; 17.7%), or also during the subsequent weeks (n = 32; 40.5%). Nodal density at planning is highly predictive of group assignment, with a larger mean density for consistently over inconsistently shrinking LNs (p =.009). Also, this grouping predicts the response at the end of treatment. Conclusion. HPV-related LN behavior during IMRT is extremely variable but somewhat predictable on the basis of nodal density at planning.
KW - IMRT
KW - lymph nodes
KW - volumetric change
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U2 - 10.1002/hed.21981
DO - 10.1002/hed.21981
M3 - Article
C2 - 22267196
AN - SCOPUS:84867889859
VL - 34
SP - 1640
EP - 1647
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 11
ER -