Volumetric differences in mapped hippocampal regions correlate with increase of high alpha rhythm in Alzheimer's disease

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Abstract

Objective. The increase of high alpha relative to low alpha power has been recently demonstrated as a reliable EEG marker of hippocampal atrophy conversion of patients with mild cognitive impairment (MCI) in Alzheimer's disease (AD). In the present study we test the reliability of this EEG index in subjects with AD. Methods. Correlation between EEG markers and volumetric differences in mapped hippocampal regions was estimated in AD patients. Results. Results show that the increase of alpha3/alpha2 power ratio is correlated with atrophy of mapped hippocampal regions in Alzheimer's disease. Conclusions. The findings confirm the possible diagnostic role of EEG markers.

Original languageEnglish
Article number208218
JournalInternational Journal of Alzheimer's Disease
DOIs
Publication statusPublished - 2011

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Alpha Rhythm
Electroencephalography
Alzheimer Disease
Atrophy
Power (Psychology)

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Ageing
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

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title = "Volumetric differences in mapped hippocampal regions correlate with increase of high alpha rhythm in Alzheimer's disease",
abstract = "Objective. The increase of high alpha relative to low alpha power has been recently demonstrated as a reliable EEG marker of hippocampal atrophy conversion of patients with mild cognitive impairment (MCI) in Alzheimer's disease (AD). In the present study we test the reliability of this EEG index in subjects with AD. Methods. Correlation between EEG markers and volumetric differences in mapped hippocampal regions was estimated in AD patients. Results. Results show that the increase of alpha3/alpha2 power ratio is correlated with atrophy of mapped hippocampal regions in Alzheimer's disease. Conclusions. The findings confirm the possible diagnostic role of EEG markers.",
author = "Moretti, {D. V.} and A. Prestia and C. Fracassi and C. Geroldi and G. Binetti and Rossini, {P. M.} and O. Zanetti and Frisoni, {G. B.}",
year = "2011",
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language = "English",
journal = "International Journal of Alzheimer's Disease",
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AU - Moretti, D. V.

AU - Prestia, A.

AU - Fracassi, C.

AU - Geroldi, C.

AU - Binetti, G.

AU - Rossini, P. M.

AU - Zanetti, O.

AU - Frisoni, G. B.

PY - 2011

Y1 - 2011

N2 - Objective. The increase of high alpha relative to low alpha power has been recently demonstrated as a reliable EEG marker of hippocampal atrophy conversion of patients with mild cognitive impairment (MCI) in Alzheimer's disease (AD). In the present study we test the reliability of this EEG index in subjects with AD. Methods. Correlation between EEG markers and volumetric differences in mapped hippocampal regions was estimated in AD patients. Results. Results show that the increase of alpha3/alpha2 power ratio is correlated with atrophy of mapped hippocampal regions in Alzheimer's disease. Conclusions. The findings confirm the possible diagnostic role of EEG markers.

AB - Objective. The increase of high alpha relative to low alpha power has been recently demonstrated as a reliable EEG marker of hippocampal atrophy conversion of patients with mild cognitive impairment (MCI) in Alzheimer's disease (AD). In the present study we test the reliability of this EEG index in subjects with AD. Methods. Correlation between EEG markers and volumetric differences in mapped hippocampal regions was estimated in AD patients. Results. Results show that the increase of alpha3/alpha2 power ratio is correlated with atrophy of mapped hippocampal regions in Alzheimer's disease. Conclusions. The findings confirm the possible diagnostic role of EEG markers.

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