Voluntary, spontaneous and reflex blinking in patients with clinically probable progressive supranuclear palsy

Matteo Bologna, Rocco Agostino, Bruno Gregori, Daniele Belvisi, Donatella Ottaviani, Carlo Colosimo, Giovanni Fabbrini, Alfredo Berardelli

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Patients with progressive supranuclear palsy (PSP) often have blinking abnormalities. In this study we examined the kinematic features of voluntary, spontaneous and reflex blinking in 11 patients with PSP and healthy control subjects. Patients were asked to blink voluntarily as fast as possible; spontaneous blinking was recorded during two 60 s rest periods; reflex blinking was evoked by electrical stimulation of the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. During voluntary blinking the closing and opening phases lasted longer in patients than in healthy subjects. Furthermore, the peak velocity of the closing phase of voluntary blinking was lower in patients than healthy subjects. During spontaneous blinking the blink rate was markedly lower in patients than in control subjects. Patient's recordings also showed kinematic abnormalities of spontaneous (reduced peak velocity of both closing and opening phases) and reflex (reduced peak velocity and increased duration of the opening phase) blinking. Recordings during reflex blinking disclosed an enhanced excitability of the interneuronal pool mediating the closing and opening blink phases. Finally, the pause, a neurophysiological marker of the switching processes between the closing and opening phases, was prolonged in all the three types of blinking. The abnormal kinematic variables correlated with patients' clinical and kinematic features. Abnormal voluntary, spontaneous and reflex blinking in patients with PSP reflects the widespread cortical, subcortical and brainstem degeneration related to this disease.

Original languageEnglish
Pages (from-to)502-510
Number of pages9
JournalBrain
Volume132
Issue number2
DOIs
Publication statusPublished - Feb 2009

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Progressive Supranuclear Palsy
Blinking
Reflex
Biomechanical Phenomena
Healthy Volunteers
Eyelids
Electric Stimulation
Brain Stem

Keywords

  • Blinking
  • Movement control
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Voluntary, spontaneous and reflex blinking in patients with clinically probable progressive supranuclear palsy. / Bologna, Matteo; Agostino, Rocco; Gregori, Bruno; Belvisi, Daniele; Ottaviani, Donatella; Colosimo, Carlo; Fabbrini, Giovanni; Berardelli, Alfredo.

In: Brain, Vol. 132, No. 2, 02.2009, p. 502-510.

Research output: Contribution to journalArticle

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