Abstract
Patients with progressive supranuclear palsy (PSP) often have blinking abnormalities. In this study we examined the kinematic features of voluntary, spontaneous and reflex blinking in 11 patients with PSP and healthy control subjects. Patients were asked to blink voluntarily as fast as possible; spontaneous blinking was recorded during two 60 s rest periods; reflex blinking was evoked by electrical stimulation of the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. During voluntary blinking the closing and opening phases lasted longer in patients than in healthy subjects. Furthermore, the peak velocity of the closing phase of voluntary blinking was lower in patients than healthy subjects. During spontaneous blinking the blink rate was markedly lower in patients than in control subjects. Patient's recordings also showed kinematic abnormalities of spontaneous (reduced peak velocity of both closing and opening phases) and reflex (reduced peak velocity and increased duration of the opening phase) blinking. Recordings during reflex blinking disclosed an enhanced excitability of the interneuronal pool mediating the closing and opening blink phases. Finally, the pause, a neurophysiological marker of the switching processes between the closing and opening phases, was prolonged in all the three types of blinking. The abnormal kinematic variables correlated with patients' clinical and kinematic features. Abnormal voluntary, spontaneous and reflex blinking in patients with PSP reflects the widespread cortical, subcortical and brainstem degeneration related to this disease.
| Original language | English |
|---|---|
| Pages (from-to) | 502-510 |
| Number of pages | 9 |
| Journal | Brain |
| Volume | 132 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2009 |
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Keywords
- Blinking
- Movement control
- Progressive supranuclear palsy
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Voluntary, spontaneous and reflex blinking in patients with clinically probable progressive supranuclear palsy. / Bologna, Matteo; Agostino, Rocco; Gregori, Bruno; Belvisi, Daniele; Ottaviani, Donatella; Colosimo, Carlo; Fabbrini, Giovanni; Berardelli, Alfredo.
In: Brain, Vol. 132, No. 2, 02.2009, p. 502-510.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Voluntary, spontaneous and reflex blinking in patients with clinically probable progressive supranuclear palsy
AU - Bologna, Matteo
AU - Agostino, Rocco
AU - Gregori, Bruno
AU - Belvisi, Daniele
AU - Ottaviani, Donatella
AU - Colosimo, Carlo
AU - Fabbrini, Giovanni
AU - Berardelli, Alfredo
PY - 2009/2
Y1 - 2009/2
N2 - Patients with progressive supranuclear palsy (PSP) often have blinking abnormalities. In this study we examined the kinematic features of voluntary, spontaneous and reflex blinking in 11 patients with PSP and healthy control subjects. Patients were asked to blink voluntarily as fast as possible; spontaneous blinking was recorded during two 60 s rest periods; reflex blinking was evoked by electrical stimulation of the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. During voluntary blinking the closing and opening phases lasted longer in patients than in healthy subjects. Furthermore, the peak velocity of the closing phase of voluntary blinking was lower in patients than healthy subjects. During spontaneous blinking the blink rate was markedly lower in patients than in control subjects. Patient's recordings also showed kinematic abnormalities of spontaneous (reduced peak velocity of both closing and opening phases) and reflex (reduced peak velocity and increased duration of the opening phase) blinking. Recordings during reflex blinking disclosed an enhanced excitability of the interneuronal pool mediating the closing and opening blink phases. Finally, the pause, a neurophysiological marker of the switching processes between the closing and opening phases, was prolonged in all the three types of blinking. The abnormal kinematic variables correlated with patients' clinical and kinematic features. Abnormal voluntary, spontaneous and reflex blinking in patients with PSP reflects the widespread cortical, subcortical and brainstem degeneration related to this disease.
AB - Patients with progressive supranuclear palsy (PSP) often have blinking abnormalities. In this study we examined the kinematic features of voluntary, spontaneous and reflex blinking in 11 patients with PSP and healthy control subjects. Patients were asked to blink voluntarily as fast as possible; spontaneous blinking was recorded during two 60 s rest periods; reflex blinking was evoked by electrical stimulation of the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. During voluntary blinking the closing and opening phases lasted longer in patients than in healthy subjects. Furthermore, the peak velocity of the closing phase of voluntary blinking was lower in patients than healthy subjects. During spontaneous blinking the blink rate was markedly lower in patients than in control subjects. Patient's recordings also showed kinematic abnormalities of spontaneous (reduced peak velocity of both closing and opening phases) and reflex (reduced peak velocity and increased duration of the opening phase) blinking. Recordings during reflex blinking disclosed an enhanced excitability of the interneuronal pool mediating the closing and opening blink phases. Finally, the pause, a neurophysiological marker of the switching processes between the closing and opening phases, was prolonged in all the three types of blinking. The abnormal kinematic variables correlated with patients' clinical and kinematic features. Abnormal voluntary, spontaneous and reflex blinking in patients with PSP reflects the widespread cortical, subcortical and brainstem degeneration related to this disease.
KW - Blinking
KW - Movement control
KW - Progressive supranuclear palsy
UR - http://www.scopus.com/inward/record.url?scp=60149101378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60149101378&partnerID=8YFLogxK
U2 - 10.1093/brain/awn317
DO - 10.1093/brain/awn317
M3 - Article
C2 - 19043083
AN - SCOPUS:60149101378
VL - 132
SP - 502
EP - 510
JO - Brain
JF - Brain
SN - 0006-8950
IS - 2
ER -