Von Willebrand disease-associated angiodysplasia: A few answers, still many questions

Massimo Franchini, Pier Mannuccio Mannucci

Research output: Contribution to journalArticlepeer-review

Abstract

The association between angiodysplasia and von Willebrand disease (VWD) has been known for more than 40 years. Bleeding in the gastrointestinal tract associated with angiodysplasia worsens the clinical course of this inherited haemorrhagic disorder and management may become difficult and challenging. Angiodysplasia associated with acquired defects or dysfunctions of von Willebrand factor (VWF) has also been reported in a variety of conditions such as monoclonal gammopathies, Heyde syndrome and in carriers of ventricular assist devices. The most recent advances concerning the mechanistic, clinical and therapeutic aspects of VWD-associated angiodysplasia are summarized in this review, together with the limitations of our knowledge that warrant further research in the frame of international cooperation.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalBritish Journal of Haematology
Volume161
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Acquired von Willebrand syndrome
  • Angiodysplasia
  • Congenital von Willebrand disease
  • Gastrointestinal bleeding

ASJC Scopus subject areas

  • Hematology

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