Von Willebrand factor: Another Janus-faced hemostasis protein

Massimo Franchini, Pier Mannuccio Mannucci

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

von Willebrand factor (VWF) is a multimeric plasma protein that mediates platelet adhesion and aggregation at sites of vascular injury and also acts as a protective carrier of factor VIII. Although the acquired or inherited deficiency of VWF is associated with a bleeding tendency, there is increasing evidence that VWF also plays a pivotal role in thrombosis. The presence in plasma of unusually large VWF multimers, due to the congenital or acquired deficiency of the VWF-cleaving metalloproteinase ADAMTS13, has been implicated in the pathogenesis of thrombotic thrombocytopenic purpura. In addition, high plasma levels of VWF have been associated with an increased risk of atherothrombosis. The current article reviews the literature and provides evidence for the two-faced character that VWF therefore represents.

Original languageEnglish
Pages (from-to)663-669
Number of pages7
JournalSeminars in Thrombosis and Hemostasis
Volume34
Issue number7
DOIs
Publication statusPublished - Oct 2008

Fingerprint

von Willebrand Factor
Hemostasis
Proteins
Thrombotic Thrombocytopenic Purpura
Vascular System Injuries
Factor VIII
Metalloproteases
Platelet Aggregation
Blood Proteins
Thrombosis
Hemorrhage
Deficiency Von willebrand factor

Keywords

  • Coronary artery disease
  • Stroke
  • Thrombosis
  • Thrombotic thrombocytopenic purpura
  • Von Willebrand factor

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Von Willebrand factor : Another Janus-faced hemostasis protein. / Franchini, Massimo; Mannucci, Pier Mannuccio.

In: Seminars in Thrombosis and Hemostasis, Vol. 34, No. 7, 10.2008, p. 663-669.

Research output: Contribution to journalArticle

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