Abstract
von Willebrand factor (VWF) is a multimeric plasma protein that mediates platelet adhesion and aggregation at sites of vascular injury and also acts as a protective carrier of factor VIII. Although the acquired or inherited deficiency of VWF is associated with a bleeding tendency, there is increasing evidence that VWF also plays a pivotal role in thrombosis. The presence in plasma of unusually large VWF multimers, due to the congenital or acquired deficiency of the VWF-cleaving metalloproteinase ADAMTS13, has been implicated in the pathogenesis of thrombotic thrombocytopenic purpura. In addition, high plasma levels of VWF have been associated with an increased risk of atherothrombosis. The current article reviews the literature and provides evidence for the two-faced character that VWF therefore represents.
| Original language | English |
|---|---|
| Pages (from-to) | 663-669 |
| Number of pages | 7 |
| Journal | Seminars in Thrombosis and Hemostasis |
| Volume | 34 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Oct 2008 |
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Keywords
- Coronary artery disease
- Stroke
- Thrombosis
- Thrombotic thrombocytopenic purpura
- Von Willebrand factor
ASJC Scopus subject areas
- Hematology
- Cardiology and Cardiovascular Medicine
Cite this
Von Willebrand factor : Another Janus-faced hemostasis protein. / Franchini, Massimo; Mannucci, Pier Mannuccio.
In: Seminars in Thrombosis and Hemostasis, Vol. 34, No. 7, 10.2008, p. 663-669.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Von Willebrand factor
T2 - Another Janus-faced hemostasis protein
AU - Franchini, Massimo
AU - Mannucci, Pier Mannuccio
PY - 2008/10
Y1 - 2008/10
N2 - von Willebrand factor (VWF) is a multimeric plasma protein that mediates platelet adhesion and aggregation at sites of vascular injury and also acts as a protective carrier of factor VIII. Although the acquired or inherited deficiency of VWF is associated with a bleeding tendency, there is increasing evidence that VWF also plays a pivotal role in thrombosis. The presence in plasma of unusually large VWF multimers, due to the congenital or acquired deficiency of the VWF-cleaving metalloproteinase ADAMTS13, has been implicated in the pathogenesis of thrombotic thrombocytopenic purpura. In addition, high plasma levels of VWF have been associated with an increased risk of atherothrombosis. The current article reviews the literature and provides evidence for the two-faced character that VWF therefore represents.
AB - von Willebrand factor (VWF) is a multimeric plasma protein that mediates platelet adhesion and aggregation at sites of vascular injury and also acts as a protective carrier of factor VIII. Although the acquired or inherited deficiency of VWF is associated with a bleeding tendency, there is increasing evidence that VWF also plays a pivotal role in thrombosis. The presence in plasma of unusually large VWF multimers, due to the congenital or acquired deficiency of the VWF-cleaving metalloproteinase ADAMTS13, has been implicated in the pathogenesis of thrombotic thrombocytopenic purpura. In addition, high plasma levels of VWF have been associated with an increased risk of atherothrombosis. The current article reviews the literature and provides evidence for the two-faced character that VWF therefore represents.
KW - Coronary artery disease
KW - Stroke
KW - Thrombosis
KW - Thrombotic thrombocytopenic purpura
KW - Von Willebrand factor
UR - http://www.scopus.com/inward/record.url?scp=58149104511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149104511&partnerID=8YFLogxK
U2 - 10.1055/s-0028-1104545
DO - 10.1055/s-0028-1104545
M3 - Article
C2 - 19085767
AN - SCOPUS:58149104511
VL - 34
SP - 663
EP - 669
JO - Seminars in Thrombosis and Hemostasis
JF - Seminars in Thrombosis and Hemostasis
SN - 0094-6176
IS - 7
ER -