Abstract
Background and aims: Endothelial dysfunction is a major determinant of the increased hepatic vascular tone of cirrhotic livers. Von Willebrand factor (vWF), P-selectin and 8-iso-PGF2α (isoprostanes), surrogate markers of endothelial dysfunction, are increased in patients with cirrhosis. This study was aimed at exploring in patients with cirrhosis and portal hypertension the relation of these endothelial factors with systemic and hepatic haemodynamics and their possible clinical prognostic value. Methods: 42 consecutive patients with cirrhosis and portal hypertension had measurement of the hepatic venous pressure gradient (HVPG), cardiopulmonary pressures and vWF, P-selectin and isoprostane levels in blood samples from hepatic and peripheral veins. Patients were followed up to 2 years, death or liver transplantation and any clinical event were recorded. Results: vWF, P-selectin and isoprostanes were increased in patients with cirrhosis compared with controls (p
| Original language | English |
|---|---|
| Pages (from-to) | 1133-1138 |
| Number of pages | 6 |
| Journal | Gut |
| Volume | 60 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2011 |
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ASJC Scopus subject areas
- Gastroenterology
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Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension. / La Mura, Vincenzo; Reverter, Juan Carlos; Flores-Arroyo, Alexandra; Raffa, Sebastián; Reverter, Enric; Seijo, Susana; Abraldes, Juan G.; Bosch, Jaime; García-Pagán, Juan Carlos.
In: Gut, Vol. 60, No. 8, 08.2011, p. 1133-1138.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension
AU - La Mura, Vincenzo
AU - Reverter, Juan Carlos
AU - Flores-Arroyo, Alexandra
AU - Raffa, Sebastián
AU - Reverter, Enric
AU - Seijo, Susana
AU - Abraldes, Juan G.
AU - Bosch, Jaime
AU - García-Pagán, Juan Carlos
PY - 2011/8
Y1 - 2011/8
N2 - Background and aims: Endothelial dysfunction is a major determinant of the increased hepatic vascular tone of cirrhotic livers. Von Willebrand factor (vWF), P-selectin and 8-iso-PGF2α (isoprostanes), surrogate markers of endothelial dysfunction, are increased in patients with cirrhosis. This study was aimed at exploring in patients with cirrhosis and portal hypertension the relation of these endothelial factors with systemic and hepatic haemodynamics and their possible clinical prognostic value. Methods: 42 consecutive patients with cirrhosis and portal hypertension had measurement of the hepatic venous pressure gradient (HVPG), cardiopulmonary pressures and vWF, P-selectin and isoprostane levels in blood samples from hepatic and peripheral veins. Patients were followed up to 2 years, death or liver transplantation and any clinical event were recorded. Results: vWF, P-selectin and isoprostanes were increased in patients with cirrhosis compared with controls (p
AB - Background and aims: Endothelial dysfunction is a major determinant of the increased hepatic vascular tone of cirrhotic livers. Von Willebrand factor (vWF), P-selectin and 8-iso-PGF2α (isoprostanes), surrogate markers of endothelial dysfunction, are increased in patients with cirrhosis. This study was aimed at exploring in patients with cirrhosis and portal hypertension the relation of these endothelial factors with systemic and hepatic haemodynamics and their possible clinical prognostic value. Methods: 42 consecutive patients with cirrhosis and portal hypertension had measurement of the hepatic venous pressure gradient (HVPG), cardiopulmonary pressures and vWF, P-selectin and isoprostane levels in blood samples from hepatic and peripheral veins. Patients were followed up to 2 years, death or liver transplantation and any clinical event were recorded. Results: vWF, P-selectin and isoprostanes were increased in patients with cirrhosis compared with controls (p
UR - http://www.scopus.com/inward/record.url?scp=79960322140&partnerID=8YFLogxK
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U2 - 10.1136/gut.2010.235689
DO - 10.1136/gut.2010.235689
M3 - Article
C2 - 21427197
AN - SCOPUS:79960322140
VL - 60
SP - 1133
EP - 1138
JO - Gut
JF - Gut
SN - 0017-5749
IS - 8
ER -