Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension

Vincenzo La Mura, Juan Carlos Reverter, Alexandra Flores-Arroyo, Sebastián Raffa, Enric Reverter, Susana Seijo, Juan G. Abraldes, Jaime Bosch, Juan Carlos García-Pagán

Research output: Contribution to journalArticle

Abstract

Background and aims: Endothelial dysfunction is a major determinant of the increased hepatic vascular tone of cirrhotic livers. Von Willebrand factor (vWF), P-selectin and 8-iso-PGF2α (isoprostanes), surrogate markers of endothelial dysfunction, are increased in patients with cirrhosis. This study was aimed at exploring in patients with cirrhosis and portal hypertension the relation of these endothelial factors with systemic and hepatic haemodynamics and their possible clinical prognostic value. Methods: 42 consecutive patients with cirrhosis and portal hypertension had measurement of the hepatic venous pressure gradient (HVPG), cardiopulmonary pressures and vWF, P-selectin and isoprostane levels in blood samples from hepatic and peripheral veins. Patients were followed up to 2 years, death or liver transplantation and any clinical event were recorded. Results: vWF, P-selectin and isoprostanes were increased in patients with cirrhosis compared with controls (p

Original languageEnglish
Pages (from-to)1133-1138
Number of pages6
JournalGut
Volume60
Issue number8
DOIs
Publication statusPublished - Aug 2011

ASJC Scopus subject areas

  • Gastroenterology

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    La Mura, V., Reverter, J. C., Flores-Arroyo, A., Raffa, S., Reverter, E., Seijo, S., Abraldes, J. G., Bosch, J., & García-Pagán, J. C. (2011). Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension. Gut, 60(8), 1133-1138. https://doi.org/10.1136/gut.2010.235689