I MULTIMERI DEL FATTORE DI VON WILLEBRAND NELLA SCLERODERMIA SISTEMICA

Translated title of the contribution: Von Willebrand factor multimers in systemic scleroderma

R. Valsecchi, T. Cainelli, E. Perticucci, E. Gotti, G. B. Vigano, G. Remuzzi, L. Naldi

Research output: Contribution to journalArticle

Abstract

In scleroderma endothelial cell damage plays an early and pivotal role in the pathogenesis of sclerotic lesions. In our study we determined whether or not plasma from 11 consecutive patients with scleroderma contained a subset of larger than normal (supranormal) multimers of von Willebrand factor which are potent inducers of platelet aggregation and adhesion. Supranormal multimers were found in all patients, but in none of the normal controls. Supranormal multimers may contribute to the pathogenesis of systemic sclerosis by inducing platelet aggregation and enhancing adhesion to subendothelium.

Translated title of the contributionVon Willebrand factor multimers in systemic scleroderma
Original languageItalian
Pages (from-to)193-196
Number of pages4
JournalGiornale Italiano di Dermatologia e Venereologia
Volume124
Issue number5
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Valsecchi, R., Cainelli, T., Perticucci, E., Gotti, E., Vigano, G. B., Remuzzi, G., & Naldi, L. (1989). I MULTIMERI DEL FATTORE DI VON WILLEBRAND NELLA SCLERODERMIA SISTEMICA. Giornale Italiano di Dermatologia e Venereologia, 124(5), 193-196.