Von willebrand factor, plasminogen activator inhibitor-1 and C-reactive protein are markers of thrombolytic efficacy in acute myocardial infarction

F. Andreotti, D. R. Hackett, A. W. Haider, M. C. Roncaglioni, G. J. Davies, J. L. Beacham, C. Kluft, A. Maseri

Research output: Contribution to journalArticle

Abstract

Plasma von Willebrand factor, plasminogen activator inhibitor activity and C-reactive protein were assessed as markers of coronary recanalisation in 30 patients with acute myocardial infarction receiving tissue-type plasminogen activator (t-PA). Blood samples were taken before t-PA (time 0), 4-hourly for 24h and daily up to 72h. A continuous electrocardiogram was recorded in the first 24h. Coronary arteriography was performed 90 min and 24h after the start of t-PA. Patients with a patent infarct artery (n=17), compared to those with occluded artery (n=13), showed a fall in von Willebrand factor from 0 to 24h (p=0.001), a greater fall in plasminogen activator inhibitor from 24 to 48h (p=0.04) and a fall in C-reactive protein from 48 to 72h (p=0.002). The accuracy of these indices compared favourably with time to peak plasma MB creatine kinase and ≥50% resolution of maximal ST-deviation on the electrocardiogram. Thus, changes in plasma von Willebrand factor, plasminogen activator inhibitor and C-reactive protein during the first 3 days of myocardial infarction are indicative of thrombolytic efficacy. Their concordant behaviour may reflect a common regulatory mechanism.

Original languageEnglish
Pages (from-to)678-682
Number of pages5
JournalThrombosis and Haemostasis
Volume68
Issue number6
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Hematology

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    Andreotti, F., Hackett, D. R., Haider, A. W., Roncaglioni, M. C., Davies, G. J., Beacham, J. L., Kluft, C., & Maseri, A. (1992). Von willebrand factor, plasminogen activator inhibitor-1 and C-reactive protein are markers of thrombolytic efficacy in acute myocardial infarction. Thrombosis and Haemostasis, 68(6), 678-682.