Von Willebrand's disease (VWD) is an inherited bleeding disorder, characterized by spontaneous hemorrhage from mucosal membranes and excessive bleeding following trauma and surgery. Since the original description of the disease, it has been recognized that the abnormalities of the hemostatic mechanism are complex, a defect of blood coagulation (factor VIII deficiency) being associated with an impaired primary hemostasis (expressed by a prolongation of the skin bleeding time). Our knowledge on VWD has considerably increased since the beginning of this decade. Such progress has largely been related to significant advances in the understanding of the structure and functions of factor VIII.
|Title of host publication||Recent Results in Cancer Research|
|Number of pages||12|
|Publication status||Published - 1979|
ASJC Scopus subject areas