Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively

M. Bozzali, M. Cercignani, F. Baglio, G. Scotti, E. Farina, L. Pugnetti, J. Ashburner, R. Nemni, A. Falini

Research output: Contribution to journalArticle

Abstract

Corticobasal degeneration (CBD) presents with symptoms that often overlap with other neurological conditions. In many cases, diagnosis, prognosis and consequent clinical management remain uncertain. Structural and functional asymmetric brain changes represent the most consistent imaging findings that may assist in CBD diagnosis. Diffusion Tensor MRI (DT-MRI) is a quantitative technique that allows microscopic tissue abnormalities to be non-invasively assessed in vivo. A single case of clinically suspected CBD with symmetric diffuse brain atrophy on conventional-MRI scans was studied using DT-MRI by voxel-wise comparison with eight healthy subjects. The lateralized distribution of DT-MRI abnormalities was consistent with clinical features providing a substantial support to the diagnosis.

Original languageEnglish
Pages (from-to)436-439
Number of pages4
JournalParkinsonism and Related Disorders
Volume14
Issue number5
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Corticobasal degeneration
  • Diffusion tensor imaging
  • EEG
  • MRI
  • SPECT

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Neurology

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