Voxel-wise magnetization transfer imaging study of effects of natalizumab and IFNβ-1a in multiple sclerosis

R. Zivadinov, M. G. Dwyer, S. Hussein, E. Carl, C. Kennedy, M. Andrews, D. Hojnacki, M. Heininen-Brown, L. Willis, M. Cherneva, N. Bergsland, B. Weinstock-Guttman

Research output: Contribution to journalArticlepeer-review


Objective: To determine the effects of intravenous natalizumab and intramuscular interferon beta-1a (IFNβ-1a) on the volume of white-matter (WM) lesions and normal appearing brain tissue (NABT) undergoing voxel-wise (VW) increases in magnetization transfer ratio (MTR) suggestive of remyelination in patients with relapsing multiple sclerosis. Methods: This prospective, open-label, single-blinded study enrolled patients with relapsing-remitting multiple sclerosis (RRMS) and relapsing secondary progressive multiple sclerosis (RSPMS) as well as a group of age/sex-matched healthy controls (n=22). Patients with multiple sclerosis were assigned to receive natalizumab monotherapy (n=77; RRMS/ RSPMS) or intramuscular IFNβ-1a (n=26) as either monotherapy (RRMS) or combined with pulsed i.v. methylprednisolone, as needed (RSPMS). The primary endpoint was the two-year change in volume of NABT VWMTR, by quantifying the number of voxels that increased (suggesting remyelination) or decreased (suggesting demyelination) in their MTR value. Results: The volume of tissue undergoing increases in VWMTR was significantly larger in natalizumab compared with IFNβ-1a-treated patients (year 1: p=0.001 in NABT and p

Original languageEnglish
Pages (from-to)1125-1134
Number of pages10
JournalMultiple Sclerosis Journal
Issue number8
Publication statusPublished - 2012


  • clinical trials observational study
  • MRI
  • multiple sclerosis
  • voxel-wise MTR

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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