Vulvar cancer: Prognostic factors

Maria Ornella Nicoletto, Anna Parenti, Paola Del Bianco, Giuseppe Lombardi, Lucia Pedrini, Sara Pizzi, Paolo Carli, Maurizia Della Palma, Davide Pastorelli, Luigi Corti, Leopoldo Becagli

Research output: Contribution to journalArticlepeer-review


Background: Prognostic factors such as surgery and pathology in vulvar squamous cell carcinoma are studied. Patients and Methods: 47 patients with vulva squamous cell carcinoma treated at the Gynecology Department of the University of Padua, have been retrospectively studied. Results: At the univariate relapse-free survival analysis, a significant association was found for histological grade, stage of disease and type of surgery. All patients presented vulvar squamous cell carcinoma: GI in 25 (53%), G 2 in 14 (30%), and G3 in 8 (17%) patients. The distribution of stages was as following: stage 1 in 6 (13%), stage 2 in 20 (43%), stage 3 in 11 (23%), and stage 4 in 10 patients (21%). Radiotherapy was performed in 13 patients. Among the 47 patients evaluable: 26 (55.3%) developed local recurrence, 12 of these patients developed a second local relapse, 3 of these also had distant metastases (lung in 1 patient, lomboaortic and mediastinic lymphnodes in the other 2 patients). Stromal invasions were ≤9 mm in 14 patients with 6 relapses and >9 mm in 30 patients with 27 relapses (univariated analysis p=0 0066). Five episodes (10,6%) of thrombosis were observed. Conclusion: After multivariate analysis, surgery, stage and stromal invasion over 9 mm (hazard ratio=3.1; 95% confidence interval: 1.3-7.7) proved to be the most dominant predictor for relapse-free survival. Histological grades 1 and 2 were predictive of better disease-free survival (p=0.0012).

Original languageEnglish
Pages (from-to)2311-2317
Number of pages7
JournalAnticancer Research
Issue number6
Publication statusPublished - Jun 2010


  • Pathological factors
  • Recurrence
  • Surgical treatment
  • Thrombosis
  • Vulvar carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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