Abstract
A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of hypomelanosis around multiple preexisting nevi of the trunk. At 18 months follow-up genital depigmentation persisted and halo nevi of the trunk were still present. Different mechanisms of imiquimod-induced depigmentation have been reported. Halo nevi are considered expression of an autoimmune response. In the case presented here, it might be conceivable that both vitiligo-like depigmentation at the site of application and halo of hypomelanosis around melanocytic nevi have been induced by the same immunologic mechanism elicited by topical application of imiquimod.
| Original language | English |
|---|---|
| Pages (from-to) | 806-807 |
| Number of pages | 2 |
| Journal | Anais Brasileiros de Dermatologia |
| Volume | 89 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Condylomata acuminata
- Halo
- Immune system
- Immune system phenomena
- Nevus
- Vitiligo
ASJC Scopus subject areas
- Dermatology
- Medicine(all)
Cite this
Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata : Casual or related events? / Serra, Maíra Chiarelli; Pennacchioli, Elisabetta; Menicanti, Claudia; Tosti, Giulio.
In: Anais Brasileiros de Dermatologia, Vol. 89, No. 5, 2014, p. 806-807.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata
T2 - Casual or related events?
AU - Serra, Maíra Chiarelli
AU - Pennacchioli, Elisabetta
AU - Menicanti, Claudia
AU - Tosti, Giulio
PY - 2014
Y1 - 2014
N2 - A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of hypomelanosis around multiple preexisting nevi of the trunk. At 18 months follow-up genital depigmentation persisted and halo nevi of the trunk were still present. Different mechanisms of imiquimod-induced depigmentation have been reported. Halo nevi are considered expression of an autoimmune response. In the case presented here, it might be conceivable that both vitiligo-like depigmentation at the site of application and halo of hypomelanosis around melanocytic nevi have been induced by the same immunologic mechanism elicited by topical application of imiquimod.
AB - A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of hypomelanosis around multiple preexisting nevi of the trunk. At 18 months follow-up genital depigmentation persisted and halo nevi of the trunk were still present. Different mechanisms of imiquimod-induced depigmentation have been reported. Halo nevi are considered expression of an autoimmune response. In the case presented here, it might be conceivable that both vitiligo-like depigmentation at the site of application and halo of hypomelanosis around melanocytic nevi have been induced by the same immunologic mechanism elicited by topical application of imiquimod.
KW - Condylomata acuminata
KW - Halo
KW - Immune system
KW - Immune system phenomena
KW - Nevus
KW - Vitiligo
UR - http://www.scopus.com/inward/record.url?scp=84906910537&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906910537&partnerID=8YFLogxK
U2 - 10.1590/abd1806-4841.20143058
DO - 10.1590/abd1806-4841.20143058
M3 - Article
VL - 89
SP - 806
EP - 807
JO - Anais Brasileiros de Dermatologia
JF - Anais Brasileiros de Dermatologia
SN - 0365-0596
IS - 5
ER -