Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata: Casual or related events?

Maíra Chiarelli Serra, Elisabetta Pennacchioli, Claudia Menicanti, Giulio Tosti

Research output: Contribution to journalArticle

Abstract

A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of hypomelanosis around multiple preexisting nevi of the trunk. At 18 months follow-up genital depigmentation persisted and halo nevi of the trunk were still present. Different mechanisms of imiquimod-induced depigmentation have been reported. Halo nevi are considered expression of an autoimmune response. In the case presented here, it might be conceivable that both vitiligo-like depigmentation at the site of application and halo of hypomelanosis around melanocytic nevi have been induced by the same immunologic mechanism elicited by topical application of imiquimod.

Original languageEnglish
Pages (from-to)806-807
Number of pages2
JournalAnais Brasileiros de Dermatologia
Volume89
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Condylomata acuminata
  • Halo
  • Immune system
  • Immune system phenomena
  • Nevus
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

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