VURD Syndrome in a female

A. Zaccara, M. P. Pascali, A. Marciano, E. Carnevale, G. Salvatori, A. Dotta, A. Nahom, M. De Gennaro

Research output: Contribution to journalArticlepeer-review


VURD syndrome has been repeatedly described as unilateral reflux into a nonfunctioning renal moiety. This syndrome is considered a pop-off mechanism dissipating pressure in lower urinary tract obstruction: it may be found in association with other protective mechanisms occurring in utero, such as ascites and/or urinomas, and has been exclusively described in male patients. A premature female baby with signs and symptoms of outflow obstruction underwent diagnostic workup revealing congenital urethral hypoplasia with unilateral reflux into a dysplastic kidney. Obstetrical history was positive for early onset, serologically negative ascites without cardiomegaly, which required serial aspirations. Reconstructive surgery was carried out with good results: ascites and VURD syndrome were both deemed to be perinatal protective mechanism against excess pressure in the urinary tract. Although rare, lower urinary tract obstruction in the female can lead to the same protective mechanisms seen in male fetuses/newborns. VURD syndrome and ascites should be interpreted as such and require perinatal specialist counselling.

Original languageEnglish
Article number852928
JournalAdvances in Urology
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Urology


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