Abstract
Background: Postoperative radiotherapy after breast-conserving surgery (BCS) is the standard in the management of breast cancer. The optimal timing for starting postoperative radiation therapy has not yet been well defined. In this study, we aimed to evaluate if the time interval between BCS and postoperative radiotherapy is related to the incidence of local and distant relapse in women with early node-negative breast cancer not receiving chemotherapy. Methods: We retrospectively analyzed clinical data concerning 615 women treated from 1984 to 2010, divided into three groups according to the timing of radiotherapy: ≤60, 61-120, and >120 days. To estimate the presence of imbalanced distribution of prognostic and treatment factors among the three groups, the χ2 test or the Fisher exact test were performed. Local relapse-free survival, distant metastasis-free survival (DMFS), and disease-free survival (DFS) were estimated with the Kaplan-Meier method, and multivariate Cox regression was used to test for the independent effect of timing of RT after adjusting for known confounding factors. The median follow-up time was 65.8 months. Results: Differences in distribution of age, type of hormone therapy, and year of diagnosis were statistically significant. At 15-year follow-up, we failed to detect a significant correlation between time interval and the risk of local relapse (p = 0.09) both at the univariate and the multivariate analysis. The DMFS and the DFS univariate analysis showed a decreased outcome when radiotherapy was started early (p = 0.041 and p = 0.046), but this was not confirmed at the multivariate analysis (p = 0.406 and p = 0.102, respectively). Conclusions: Our results show that no correlation exists between the timing of postoperative radiotherapy and the risk of local relapse or distant metastasis development in a particular subgroup of women with node-negative early breast cancer.
| Original language | English |
|---|---|
| Article number | 32 |
| Journal | European Journal of Medical Research |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Distant metastases
- Early-stage breast cancer
- Local relapse
- Radiotherapy
- Survival
- Timing
ASJC Scopus subject areas
- Medicine(all)
Cite this
Waiting time for radiation therapy after breast-conserving surgery in early breast cancer : A retrospective analysis of local relapse and distant metastases in 615 patients. / Caponio, Raffaella; Ciliberti, Maria Paola; Graziano, Giusi; Necchia, Rocco; Scognamillo, Giovanni; Pascali, Antonio; Bonaduce, Sabino; Milella, Anna; Matichecchia, Gabriele; Cristofaro, Cristian; Di Fatta, Davide; Tamborra, Pasquale; Lioce, Marco.
In: European Journal of Medical Research, Vol. 21, No. 1, 32, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Waiting time for radiation therapy after breast-conserving surgery in early breast cancer
T2 - A retrospective analysis of local relapse and distant metastases in 615 patients
AU - Caponio, Raffaella
AU - Ciliberti, Maria Paola
AU - Graziano, Giusi
AU - Necchia, Rocco
AU - Scognamillo, Giovanni
AU - Pascali, Antonio
AU - Bonaduce, Sabino
AU - Milella, Anna
AU - Matichecchia, Gabriele
AU - Cristofaro, Cristian
AU - Di Fatta, Davide
AU - Tamborra, Pasquale
AU - Lioce, Marco
PY - 2016
Y1 - 2016
N2 - Background: Postoperative radiotherapy after breast-conserving surgery (BCS) is the standard in the management of breast cancer. The optimal timing for starting postoperative radiation therapy has not yet been well defined. In this study, we aimed to evaluate if the time interval between BCS and postoperative radiotherapy is related to the incidence of local and distant relapse in women with early node-negative breast cancer not receiving chemotherapy. Methods: We retrospectively analyzed clinical data concerning 615 women treated from 1984 to 2010, divided into three groups according to the timing of radiotherapy: ≤60, 61-120, and >120 days. To estimate the presence of imbalanced distribution of prognostic and treatment factors among the three groups, the χ2 test or the Fisher exact test were performed. Local relapse-free survival, distant metastasis-free survival (DMFS), and disease-free survival (DFS) were estimated with the Kaplan-Meier method, and multivariate Cox regression was used to test for the independent effect of timing of RT after adjusting for known confounding factors. The median follow-up time was 65.8 months. Results: Differences in distribution of age, type of hormone therapy, and year of diagnosis were statistically significant. At 15-year follow-up, we failed to detect a significant correlation between time interval and the risk of local relapse (p = 0.09) both at the univariate and the multivariate analysis. The DMFS and the DFS univariate analysis showed a decreased outcome when radiotherapy was started early (p = 0.041 and p = 0.046), but this was not confirmed at the multivariate analysis (p = 0.406 and p = 0.102, respectively). Conclusions: Our results show that no correlation exists between the timing of postoperative radiotherapy and the risk of local relapse or distant metastasis development in a particular subgroup of women with node-negative early breast cancer.
AB - Background: Postoperative radiotherapy after breast-conserving surgery (BCS) is the standard in the management of breast cancer. The optimal timing for starting postoperative radiation therapy has not yet been well defined. In this study, we aimed to evaluate if the time interval between BCS and postoperative radiotherapy is related to the incidence of local and distant relapse in women with early node-negative breast cancer not receiving chemotherapy. Methods: We retrospectively analyzed clinical data concerning 615 women treated from 1984 to 2010, divided into three groups according to the timing of radiotherapy: ≤60, 61-120, and >120 days. To estimate the presence of imbalanced distribution of prognostic and treatment factors among the three groups, the χ2 test or the Fisher exact test were performed. Local relapse-free survival, distant metastasis-free survival (DMFS), and disease-free survival (DFS) were estimated with the Kaplan-Meier method, and multivariate Cox regression was used to test for the independent effect of timing of RT after adjusting for known confounding factors. The median follow-up time was 65.8 months. Results: Differences in distribution of age, type of hormone therapy, and year of diagnosis were statistically significant. At 15-year follow-up, we failed to detect a significant correlation between time interval and the risk of local relapse (p = 0.09) both at the univariate and the multivariate analysis. The DMFS and the DFS univariate analysis showed a decreased outcome when radiotherapy was started early (p = 0.041 and p = 0.046), but this was not confirmed at the multivariate analysis (p = 0.406 and p = 0.102, respectively). Conclusions: Our results show that no correlation exists between the timing of postoperative radiotherapy and the risk of local relapse or distant metastasis development in a particular subgroup of women with node-negative early breast cancer.
KW - Distant metastases
KW - Early-stage breast cancer
KW - Local relapse
KW - Radiotherapy
KW - Survival
KW - Timing
UR - http://www.scopus.com/inward/record.url?scp=84992123215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992123215&partnerID=8YFLogxK
U2 - 10.1186/s40001-016-0226-9
DO - 10.1186/s40001-016-0226-9
M3 - Article
AN - SCOPUS:84992123215
VL - 21
JO - European Journal of Medical Research
JF - European Journal of Medical Research
SN - 0949-2321
IS - 1
M1 - 32
ER -