Walker carcinoma 256: A model for studies on tumor-induced anorexia and cachexia

Amalia Guaitani, Martino Recchia, Miriana Carlit, Maurizio Rocchetti, Ivan Bartošek, Silvio Garatiini

Research output: Contribution to journalArticle

Abstract

Data on anorexia and cachexia induced by Walker carcinoma 256 in Sprague-Dawley rats were analyzed in order to standardize an experimental model using a statistical (nondeterministical) procedure for assessing the efficacy of potential orexigenic agents. This model was characterized by a mean survival time of 14 ± 1 days and by food intake and body weight loss starting from day 6 after tumor implantation. The complex course of cachexia was characterized by reduction in the weight of gastrocnemius muscle and epididymal adipose tissue, taken as representative sites of loss of proteins and lipids.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalOncology
Volume39
Issue number3
DOIs
Publication statusPublished - 1982

Keywords

  • Anorexia
  • Bpididymal adipose tissue
  • Cachexia Gastroenemius muscle
  • Linear regression
  • Walker carcinoma 256

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Guaitani, A., Recchia, M., Carlit, M., Rocchetti, M., Bartošek, I., & Garatiini, S. (1982). Walker carcinoma 256: A model for studies on tumor-induced anorexia and cachexia. Oncology, 39(3), 173-178. https://doi.org/10.1159/000225631