Abstract
Background and aim of the work: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality rates and a median survival of 2-3 years from time of diagnosis. The prognosis for any individual patient, however, is variable. To elucidate the clinical significance of 6-min walking test (6-MWT) in patients with IPF, we sought to assess the relationship between distance walked and desaturation during this test and pulmonary function tests (PFTs). We also evaluate the prognostic value of 6-MWT in comparison with PFTs at baseline and during follow-up. Methods: The clinical data of 44 patients with IPF were retrospectively analysed. Twenty-nine patients had an additional evaluation after 12 month of follow-up. Results: Distance walked in 6 min was independently related to mortality by multivariate analysis. Patients walking less then 212 m had a significantly lower survival than those walking farther, assessed by Kaplan-Meier survival curves (log-rank test, p <0.036). During a mean follow-up period of 19.8 months (range 3.2-46.4), 11 patients died of causes related to disease. Changes in meters walked at 12 months evaluation were also predictive of survival (p = 0.05). Conclusions: These results confirm that in IPF distance walked in 6 min is independent associated with mortality.
| Original language | English |
|---|---|
| Pages (from-to) | 117-123 |
| Number of pages | 7 |
| Journal | Respiratory Medicine |
| Volume | 103 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2009 |
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Keywords
- 6-MWT
- Interstitial lung diseases
- Prognostic factor
- Pulmonary fibrosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Walking distance on 6-MWT is a prognostic factor in idiopathic pulmonary fibrosis. / Caminati, Antonella; Bianchi, Achille; Cassandro, Roberto; Rosa Mirenda, Maria; Harari, Sergio.
In: Respiratory Medicine, Vol. 103, No. 1, 01.2009, p. 117-123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Walking distance on 6-MWT is a prognostic factor in idiopathic pulmonary fibrosis
AU - Caminati, Antonella
AU - Bianchi, Achille
AU - Cassandro, Roberto
AU - Rosa Mirenda, Maria
AU - Harari, Sergio
PY - 2009/1
Y1 - 2009/1
N2 - Background and aim of the work: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality rates and a median survival of 2-3 years from time of diagnosis. The prognosis for any individual patient, however, is variable. To elucidate the clinical significance of 6-min walking test (6-MWT) in patients with IPF, we sought to assess the relationship between distance walked and desaturation during this test and pulmonary function tests (PFTs). We also evaluate the prognostic value of 6-MWT in comparison with PFTs at baseline and during follow-up. Methods: The clinical data of 44 patients with IPF were retrospectively analysed. Twenty-nine patients had an additional evaluation after 12 month of follow-up. Results: Distance walked in 6 min was independently related to mortality by multivariate analysis. Patients walking less then 212 m had a significantly lower survival than those walking farther, assessed by Kaplan-Meier survival curves (log-rank test, p <0.036). During a mean follow-up period of 19.8 months (range 3.2-46.4), 11 patients died of causes related to disease. Changes in meters walked at 12 months evaluation were also predictive of survival (p = 0.05). Conclusions: These results confirm that in IPF distance walked in 6 min is independent associated with mortality.
AB - Background and aim of the work: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality rates and a median survival of 2-3 years from time of diagnosis. The prognosis for any individual patient, however, is variable. To elucidate the clinical significance of 6-min walking test (6-MWT) in patients with IPF, we sought to assess the relationship between distance walked and desaturation during this test and pulmonary function tests (PFTs). We also evaluate the prognostic value of 6-MWT in comparison with PFTs at baseline and during follow-up. Methods: The clinical data of 44 patients with IPF were retrospectively analysed. Twenty-nine patients had an additional evaluation after 12 month of follow-up. Results: Distance walked in 6 min was independently related to mortality by multivariate analysis. Patients walking less then 212 m had a significantly lower survival than those walking farther, assessed by Kaplan-Meier survival curves (log-rank test, p <0.036). During a mean follow-up period of 19.8 months (range 3.2-46.4), 11 patients died of causes related to disease. Changes in meters walked at 12 months evaluation were also predictive of survival (p = 0.05). Conclusions: These results confirm that in IPF distance walked in 6 min is independent associated with mortality.
KW - 6-MWT
KW - Interstitial lung diseases
KW - Prognostic factor
KW - Pulmonary fibrosis
UR - http://www.scopus.com/inward/record.url?scp=57949084974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57949084974&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2008.07.022
DO - 10.1016/j.rmed.2008.07.022
M3 - Article
C2 - 18786822
AN - SCOPUS:57949084974
VL - 103
SP - 117
EP - 123
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 1
ER -