Wandering spleen: 'Presentation in adolescent with high thrombotic risk'

Hyppolite K. Tchidjou, Maria A. Castelluzzo, Virginia Messia, Matteo Luciani, Lidia Monti, Chiara Grimaldi, Stefania Bernardi, Patrizia D'Argenio

Research output: Contribution to journalArticlepeer-review


The term 'wandering spleen' refers to an abnormal hypermobility of the spleen, which may be congenital or acquired. The absence or abnormal laxity of splenic ligaments combined with an abnormally long and mobile vascular pedicle predispose to complications such as torsion of the splenic pedicle, infarction and splenic vein thrombosis. The clinical presentation of such disease is highly variable. In this case, we describe an asymptomatic case of wandering spleen in high thrombotic risk patients with cavernoma of splenic vein and infarction of the spleen. Physical examination was normal except the enlarged and no tender consistency spleen palpable at left iliac fossa. Ultrasonography revealed enlarged spleniform mass below its normal position suggesting vascular impairment and subsequently has been confirmed by colour Doppler ultrasound and computed tomography. The family history was positive for ischemic thrombotic vascular diseases and the screening for thrombotic risk has revealed hyperhomocysteinemia, thrombophilic homozygous gene mutations for factor V (H1299R) and MTHFR (C677T). For high thrombotic risk, prophylaxis postsplenectomy was suggested according to the international recommendations with subcutaneous low molecular weight heparin, associated with a preventive treatment with acetyl salicylic acid and folic acid along with B-vitamin. This case report may be helpful for clinicians involved in the care of splenectomized patients, because it has shown the importance of an appropriate pre and postoperative antithrombotic management to reduce as soon as possible the risk of thrombotic events in such patients after splenectomy.

Original languageEnglish
Pages (from-to)530-533
Number of pages4
JournalBlood Coagulation and Fibrinolysis
Issue number5
Publication statusPublished - 2014


  • Antithrombotic prophylaxis
  • Splenectomy
  • Thrombophilic screening
  • Thrombotic risk

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)


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