Warfarin inhibits both procoagulant activity and metastatic capacity of Lewis Lung Carcinoma cells. Role of vitamin K deficiency

Mario Colucci, Federica Delaini, Germana De Bellis Vitti, Daniela Locati, Andreina Poggi, Nicola Semeraro, Maria Benedetta Donati

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic vitamin K deficiency, either dietary or pharmacologically induced with warfarin, depressed significantly the growth of lung secondaries in a spontaneously metastasizing murine tumor, the Lewis Lung Carcinoma. This effect was associated with a marked depression of the procoagulant activity of cancer cells, which could contribute to fibrin deposition around the tumor. Cellular anticoagulation may thus be an important mechanism in the antimetastatic effect of warfarin.

Original languageEnglish
Pages (from-to)1689-1691
Number of pages3
JournalBiochemical Pharmacology
Volume32
Issue number11
DOIs
Publication statusPublished - Jun 1 1983

ASJC Scopus subject areas

  • Pharmacology

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