Warmth and nociceptive evoked potentials in cold-induced sweating syndrome type 1

Elisa Testani, Giacomo Della Marca, Ilaria La Torraca, Catello Vollono, Giangiorgio Crisponi, Giuseppe Zampino, Massimiliano Valeriani

Research output: Contribution to journalArticlepeer-review


Introduction: Cold-induced sweating syndrome type 1 (CISS1), is a rare, severe, autosomal recessive disease. It is characterized by morphological alterations and profuse sweating when ambient temperature is 2 laser-evoked potentials (LEPs) in patients affected by CISS1. Methods: Four patients were studied. Laser pulses were applied to the skin of the right hand and the perioral region at painful intensity to record Aδ-LEPs, and at non-painful intensity to obtain C-LEPs. Fifteen healthy subjects were studied for control purposes. Results: No significant difference in latencies or amplitudes of either Aδ- or C-LEPs was found between the 2 groups. Conclusion: Cutaneous nociceptive and warmth pathway functions are normal in CISS1. Muscle Nerve 54: 100–103, 2016.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalMuscle and Nerve
Issue number1
Publication statusPublished - Jul 1 2016


  • Aδ-fibers
  • C-fibers
  • CISS1
  • cold-induced sweating
  • laser-evoked potentials

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology


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