Background: We evaluated the relationship between diabetes and temporal characteristics of cardiac risk at long-term follow-up in a propensity score-matched cohort of diabetic and non-diabetic patients with normal stress myocardial perfusion single-photon emission computed tomography (MPS). Methods and Results: We studied 828 consecutive patients with suspected or known coronary artery disease and normal perfusion at stress MPS. To account for differences in baseline characteristics between diabetics and non-diabetics, we created a propensity score-matched cohort considering clinical variables and stress type. After matching, clinical characteristics were comparable in 260 diabetic and 260 non-diabetic patients. All patients were followed for at least 1 year (median 53 months). End-point events were cardiac death or nonfatal myocardial infarction. At Cox analysis, diabetes (hazard ratio 3.9, P 45% remained at low risk for the entire length of follow-up, while the highest probability of events and the major risk acceleration was observed in patients with diabetes and post-stress LVEF ≤45%. Conclusions: After a normal stress MPS, diabetic patients are at higher risk for cardiac events than non-diabetic subjects also after balancing clinical characteristics and stress type by propensity score analysis. The warranty period of a normal stress MPS varies according to diabetic status and post-stress LVEF.
- diabetes mellitus
- Myocardial perfusion imaging
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging