Warthin-like tumour of the thyroid gland: RET/PTC expression indicates it is a variant of papillary carcinoma

A. D'Antonio, A. De Chiara, M. Santoro, G. Chiappetta, N. S. Losito

Research output: Contribution to journalArticle

Abstract

Aims: Three cases with features of so-called 'Warthin-like tumour' of the thyroid (WaLTT) are described, in order to evaluate its relationship with papillary carcinoma (PC). Methods and results: We performed an histological and immunohistochemical study with emphasis on RET/PTC expression. The most striking features are represented by marked lymphocytic infiltration in the stalks of papillae and by oxyphilic metaplasia of epithelium, resembling Warthin tumour of the salivary gland. In all cases, we found nuclear features reminiscent of PC. The neoplastic cells were strongly positive for Leu M1 and epithelial membrane antigen (EMA), less for thyroglobulin and negative for calcitonin. The lymphocytic infiltrate was composed of a mixed population of B and T-cells with sparse S100-positive Langerhans cells. An interesting finding was the strong positivity with the antibody against RET/PTC. Conclusion: All clinicopathological data along with the presence of the extensive lymphocytic infiltrate could imply a more favourable prognosis. The expression of RET/PTC fusion gene adds support to the hypothesis that this tumour is a variant of PC, probably related to the oncocytic variant of PC.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalHistopathology
Volume36
Issue number6
Publication statusPublished - 2000

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Adenolymphoma
Factor IX
Papillary Carcinoma
Thyroid Gland
Mucin-1
Langerhans Cells
Thyroglobulin
Gene Fusion
Metaplasia
Calcitonin
Salivary Glands
Epithelium
T-Lymphocytes
Antibodies
Population
Neoplasms

Keywords

  • Papillary carcinoma
  • RET/PTC
  • Thyroid
  • Warthin-like

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Warthin-like tumour of the thyroid gland : RET/PTC expression indicates it is a variant of papillary carcinoma. / D'Antonio, A.; De Chiara, A.; Santoro, M.; Chiappetta, G.; Losito, N. S.

In: Histopathology, Vol. 36, No. 6, 2000, p. 493-498.

Research output: Contribution to journalArticle

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AU - De Chiara, A.

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AU - Chiappetta, G.

AU - Losito, N. S.

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