Wasting as an independent predictor of mortality in patients with cystic fibrosis

R. Sharma, V. G. Florea, A. P. Bolger, W. Doehner, N. D. Florea, A. J S Coats, M. E. Hodson, S. D. Anker, M. Y. Henein

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Background - Cystic fibrosis (CF) is the most common life threatening autosomal recessive disorder in the white population. Wasting has long been recognised as a poor prognostic marker in CF. Whether it predicts survival independently of lung function and arterial blood gas tensions has not previously been reported. Methods - 584 patients with CF (261 women) of mean (SD) age 21 (7) years were studied between 1985 and 1996, all of whom were being followed up in a tertiary referral centre. Lung function tests, body weight, arterial blood oxygen (Pao2) and carbon dioxide (Paco2) tensions were measured. The weight was calculated as a percentage of the ideal body weight for age, height, and sex. Results - Forced expiratory volume in one second (FEV1) recorded at the start of the study was 1.8 (1.0)1 (52 (26)% predicted FEV1), Pao2 9.8 (1.9) kPa, Paco2 5.0 (0.9) kPa, and % ideal weight 92 (18)%. During the follow up period (45 (27) months) 137 patients died (5 year survival 72%, 95% CI 67 to 73). FEV1, % predicted FEV1, Pao2, % ideal weight (all p2 (p=0.04) predicted survival. In multivariate analysis, % predicted FEV1 (p2 (p=0.02) were independent predictors of outcome. Patients with >85% ideal body weight had a better prognosis at 5 years (cumulative survival 84%, 95% CI 79 to 89) than those with ≤85% ideal weight (survival 53%, 95% CI 45 to 62), p1 (area under curve 0.83; 95% CI 0.78 to 0.87) and % ideal weight (area under curve 0.74; 95% CI 0.68 to 0.79) were accurate predictors of survival at 5 years follow up (receiver-operating characteristic analysis). Conclusions - Body wasting is a significant predictor of survival in patients with CF independent of lung function, arterial blood oxygen and carbon dioxide tensions.

Original languageEnglish
Pages (from-to)746-750
Number of pages5
JournalThorax
Volume56
Issue number10
DOIs
Publication statusPublished - 2001

Fingerprint

Cystic Fibrosis
Survival
Mortality
Weights and Measures
Ideal Body Weight
Carbon Dioxide
Area Under Curve
Oxygen
Lung
Respiratory Function Tests
Forced Expiratory Volume
Tertiary Care Centers
ROC Curve
Multivariate Analysis
Gases
Body Weight
Population

Keywords

  • Cystic fibrosis
  • Survival
  • Wasting

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Sharma, R., Florea, V. G., Bolger, A. P., Doehner, W., Florea, N. D., Coats, A. J. S., ... Henein, M. Y. (2001). Wasting as an independent predictor of mortality in patients with cystic fibrosis. Thorax, 56(10), 746-750. https://doi.org/10.1136/thorax.56.10.746

Wasting as an independent predictor of mortality in patients with cystic fibrosis. / Sharma, R.; Florea, V. G.; Bolger, A. P.; Doehner, W.; Florea, N. D.; Coats, A. J S; Hodson, M. E.; Anker, S. D.; Henein, M. Y.

In: Thorax, Vol. 56, No. 10, 2001, p. 746-750.

Research output: Contribution to journalArticle

Sharma, R, Florea, VG, Bolger, AP, Doehner, W, Florea, ND, Coats, AJS, Hodson, ME, Anker, SD & Henein, MY 2001, 'Wasting as an independent predictor of mortality in patients with cystic fibrosis', Thorax, vol. 56, no. 10, pp. 746-750. https://doi.org/10.1136/thorax.56.10.746
Sharma R, Florea VG, Bolger AP, Doehner W, Florea ND, Coats AJS et al. Wasting as an independent predictor of mortality in patients with cystic fibrosis. Thorax. 2001;56(10):746-750. https://doi.org/10.1136/thorax.56.10.746
Sharma, R. ; Florea, V. G. ; Bolger, A. P. ; Doehner, W. ; Florea, N. D. ; Coats, A. J S ; Hodson, M. E. ; Anker, S. D. ; Henein, M. Y. / Wasting as an independent predictor of mortality in patients with cystic fibrosis. In: Thorax. 2001 ; Vol. 56, No. 10. pp. 746-750.
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T1 - Wasting as an independent predictor of mortality in patients with cystic fibrosis

AU - Sharma, R.

AU - Florea, V. G.

AU - Bolger, A. P.

AU - Doehner, W.

AU - Florea, N. D.

AU - Coats, A. J S

AU - Hodson, M. E.

AU - Anker, S. D.

AU - Henein, M. Y.

PY - 2001

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N2 - Background - Cystic fibrosis (CF) is the most common life threatening autosomal recessive disorder in the white population. Wasting has long been recognised as a poor prognostic marker in CF. Whether it predicts survival independently of lung function and arterial blood gas tensions has not previously been reported. Methods - 584 patients with CF (261 women) of mean (SD) age 21 (7) years were studied between 1985 and 1996, all of whom were being followed up in a tertiary referral centre. Lung function tests, body weight, arterial blood oxygen (Pao2) and carbon dioxide (Paco2) tensions were measured. The weight was calculated as a percentage of the ideal body weight for age, height, and sex. Results - Forced expiratory volume in one second (FEV1) recorded at the start of the study was 1.8 (1.0)1 (52 (26)% predicted FEV1), Pao2 9.8 (1.9) kPa, Paco2 5.0 (0.9) kPa, and % ideal weight 92 (18)%. During the follow up period (45 (27) months) 137 patients died (5 year survival 72%, 95% CI 67 to 73). FEV1, % predicted FEV1, Pao2, % ideal weight (all p2 (p=0.04) predicted survival. In multivariate analysis, % predicted FEV1 (p2 (p=0.02) were independent predictors of outcome. Patients with >85% ideal body weight had a better prognosis at 5 years (cumulative survival 84%, 95% CI 79 to 89) than those with ≤85% ideal weight (survival 53%, 95% CI 45 to 62), p1 (area under curve 0.83; 95% CI 0.78 to 0.87) and % ideal weight (area under curve 0.74; 95% CI 0.68 to 0.79) were accurate predictors of survival at 5 years follow up (receiver-operating characteristic analysis). Conclusions - Body wasting is a significant predictor of survival in patients with CF independent of lung function, arterial blood oxygen and carbon dioxide tensions.

AB - Background - Cystic fibrosis (CF) is the most common life threatening autosomal recessive disorder in the white population. Wasting has long been recognised as a poor prognostic marker in CF. Whether it predicts survival independently of lung function and arterial blood gas tensions has not previously been reported. Methods - 584 patients with CF (261 women) of mean (SD) age 21 (7) years were studied between 1985 and 1996, all of whom were being followed up in a tertiary referral centre. Lung function tests, body weight, arterial blood oxygen (Pao2) and carbon dioxide (Paco2) tensions were measured. The weight was calculated as a percentage of the ideal body weight for age, height, and sex. Results - Forced expiratory volume in one second (FEV1) recorded at the start of the study was 1.8 (1.0)1 (52 (26)% predicted FEV1), Pao2 9.8 (1.9) kPa, Paco2 5.0 (0.9) kPa, and % ideal weight 92 (18)%. During the follow up period (45 (27) months) 137 patients died (5 year survival 72%, 95% CI 67 to 73). FEV1, % predicted FEV1, Pao2, % ideal weight (all p2 (p=0.04) predicted survival. In multivariate analysis, % predicted FEV1 (p2 (p=0.02) were independent predictors of outcome. Patients with >85% ideal body weight had a better prognosis at 5 years (cumulative survival 84%, 95% CI 79 to 89) than those with ≤85% ideal weight (survival 53%, 95% CI 45 to 62), p1 (area under curve 0.83; 95% CI 0.78 to 0.87) and % ideal weight (area under curve 0.74; 95% CI 0.68 to 0.79) were accurate predictors of survival at 5 years follow up (receiver-operating characteristic analysis). Conclusions - Body wasting is a significant predictor of survival in patients with CF independent of lung function, arterial blood oxygen and carbon dioxide tensions.

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