Wasting of the left ventricle in patients with cardiac cachexia: A cardiovascular magnetic resonance study

Viorel G. Florea, James Moon, Dudley J. Pennell, Wolfram Doehner, Andrew J S Coats, Stefan D. Anker

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The "cachectic heart" has been described as a pathologic decrease in the size and mass of the heart, but no in vivo studies have shown changes in cardiac dimensions or left ventricular (LV) mass over time in chronic heart failure (CHF) associated with body wasting (cardiac cachexia). Cardiovascular magnetic resonance (CMR) has high reproducibility and is more sensitive than other techniques. Methods: CMR studies of LV volumes and mass were performed at baseline and a mean of 15 months later in nine CHF patients with cardiac cachexia and 28 matched CHF controls without cachexia (mass index 23±1 vs. 29±5 kg/m2, P=0.0005). Results: At baseline, LV end-diastolic volume (197±78 vs. 203±65 ml), end-systolic volume (131±75 vs. 126±63 ml), LV mass (213±44 vs. 222±62 g), and LV ejection fraction (38±19% vs. 40±16%) did not differ between cachectic patients and controls (all P>0.10). During follow-up, there was a significant decrease in LV mass in patients with cachexia (-16 g, P

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalInternational Journal of Cardiology
Volume97
Issue number1
DOIs
Publication statusPublished - Oct 2004

Keywords

  • Cardiac cachexia
  • Heart failure
  • Left ventricular mass
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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