Waxy casts in the urinary sediment of patients with different types of glomerular diseases: Results of a prospective study

Diana Spinelli, Dario Consonni, Giuseppe Garigali, Giovanni B. Fogazzi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Casts are well known components of the urinary sediment. For most casts, the clinical associations are known and demonstrated, while for waxy casts they are totally unknown. Methods: Prospective study for the search and count of waxy casts in the urinary sediment of patients with different types of glomerular diseases. Results: Waxy casts were found in 39 out of 287 patients (13.6%), mostly in low number (1 to 9 out of 100 casts evaluated/sample). They were frequent in postinfectious glomerulonephritis and renal amyloidosis (5/9 patients, 44.5%, p=. 0.02 for each condition), while they were rare in membranous nephropathy (4/67 patients, 6.0%, 0.04) and absent in focal segmental glomerulosclerosis (0/23 patients, p=. 0.05). Waxy casts were associated significantly with higher serum creatinine levels (. p. 1 leukocyte/HPF, granular casts and leukocytic casts (. p=. 0.001 to 0.008) and with higher numbers of erythrocytes, leukocytes, renal tubular epithelial cells, granular casts, epithelial casts, and leukocytic casts (. p

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalClinica Chimica Acta
Volume424
DOIs
Publication statusPublished - Sep 23 2013

Keywords

  • Glomerulonephritis
  • Urinalysis
  • Urinary casts
  • Urinary sediment
  • Waxy casts

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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