WAY 100635, a 5-HT(1A) receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chloro-kynurenic acid

Mirjana Carli, Pierenrico Bonalumi, Rosario Samanin

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of WAY 100635, a 5-HT(1A) receptor antagonist, on the impairment of spatial learning caused by intrahippocampal administration of scopolamine, a cholinergic muscarinic receptor antagonist, or 7-chloro- kynurenic acid, an antagonist at the glycine site associated with the NMDA receptor complex, was studied in a two-platform spatial discrimination task. Scopolamine (4 μg/μl) or 7-chloro-kynurenic acid (3 μg/μl), administered bilaterally into the CA1 region of the dorsal hippocampus 10 min before each training session, impaired choice accuracy with no effect on choice latency and errors of omission. Administered subcutaneously at 1 (but not at 0.3) mg/kg 30 min before each training session, WAY 100635 did not modify the acquisition of spatial learning, but prevented the impairment of choice accuracy caused by intrahippocampal scopolamine or 7-chloro-kynurenic acid. These findings suggest that blockade of 5-HT(1A) receptors can compensate the loss of cholinergic or NMDA-mediated excitatory input to pyramidal cells in the hippocampus. The mechanisms involved and the importance of these findings for the symptomatic treatment of memory disorders in man are discussed.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalBrain Research
Volume774
Issue number1-2
DOIs
Publication statusPublished - Nov 7 1997

Keywords

  • 7-Chloro-kynurenic acid
  • Glycine site
  • Hippocampus
  • NMDA receptor
  • Rat
  • Scopolamine
  • Serotonin 5-HT(1A) receptor
  • Spatial learning
  • WAY 100635

ASJC Scopus subject areas

  • Neuroscience(all)

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