Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials

Calvin J. Cohen; Jean Michel Molina; Isabel Cassetti; Ploenchan Chetchotisakd; Adriano Lazzarin; Chloe Orkin; Frank Rhame; Hans Jürgen Stellbrink; Taisheng Li; Herta Crauwels; Laurence Rimsky; Simon Vanveggel; Peter Williams; Katia Boven

doi:10.1097/QAD.0b013e32835cee6e

Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials

Calvin J. Cohen, Jean Michel Molina, Isabel Cassetti, Ploenchan Chetchotisakd, Adriano Lazzarin, Chloe Orkin, Frank Rhame, Hans Jürgen Stellbrink, Taisheng Li, Herta Crauwels, Laurence Rimsky, Simon Vanveggel, Peter Williams, Katia Boven

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Background: In the week 48 primary analysis of ECHO and THRIVE, rilpivirine demonstrated noninferior efficacy and more favourable tolerability versus efavirenz in treatment-naive, HIV-1-infected adults. Pooled 96-week results are presented. Methods: Patients (N1/41368) received rilpivirine 25mg once-daily (q.d.) or efavirenz 600mg q.d., with two background nucleoside/nucleotide reverse transcriptase inhibitors, in two randomized, double-blind, double-dummy Phase III trials. Results: At week 96, response rate (% confirmed viral load

Original language	English
Pages (from-to)	939-950
Number of pages	12
Journal	AIDS (London, England)
Volume	27
Issue number	6
DOIs	https://doi.org/10.1097/QAD.0b013e32835cee6e
Publication status	Published - Mar 27 2013

Keywords

Efavirenz
HIV-1
Rilpivirine
Treatment naive

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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Cohen, C. J., Molina, J. M., Cassetti, I., Chetchotisakd, P., Lazzarin, A., Orkin, C., Rhame, F., Stellbrink, H. J., Li, T., Crauwels, H., Rimsky, L., Vanveggel, S., Williams, P., & Boven, K. (2013). Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials. AIDS (London, England), 27(6), 939-950. https://doi.org/10.1097/QAD.0b013e32835cee6e

Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials. / Cohen, Calvin J.; Molina, Jean Michel; Cassetti, Isabel; Chetchotisakd, Ploenchan; Lazzarin, Adriano; Orkin, Chloe; Rhame, Frank; Stellbrink, Hans Jürgen; Li, Taisheng; Crauwels, Herta; Rimsky, Laurence; Vanveggel, Simon; Williams, Peter; Boven, Katia.

In: AIDS (London, England), Vol. 27, No. 6, 27.03.2013, p. 939-950.

Research output: Contribution to journal › Article

Cohen, CJ, Molina, JM, Cassetti, I, Chetchotisakd, P, Lazzarin, A, Orkin, C, Rhame, F, Stellbrink, HJ, Li, T, Crauwels, H, Rimsky, L, Vanveggel, S, Williams, P & Boven, K 2013, 'Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials', AIDS (London, England), vol. 27, no. 6, pp. 939-950. https://doi.org/10.1097/QAD.0b013e32835cee6e

Cohen, Calvin J. ; Molina, Jean Michel ; Cassetti, Isabel ; Chetchotisakd, Ploenchan ; Lazzarin, Adriano ; Orkin, Chloe ; Rhame, Frank ; Stellbrink, Hans Jürgen ; Li, Taisheng ; Crauwels, Herta ; Rimsky, Laurence ; Vanveggel, Simon ; Williams, Peter ; Boven, Katia. / Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials. In: AIDS (London, England). 2013 ; Vol. 27, No. 6. pp. 939-950.

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abstract = "Background: In the week 48 primary analysis of ECHO and THRIVE, rilpivirine demonstrated noninferior efficacy and more favourable tolerability versus efavirenz in treatment-naive, HIV-1-infected adults. Pooled 96-week results are presented. Methods: Patients (N1/41368) received rilpivirine 25mg once-daily (q.d.) or efavirenz 600mg q.d., with two background nucleoside/nucleotide reverse transcriptase inhibitors, in two randomized, double-blind, double-dummy Phase III trials. Results: At week 96, response rate (% confirmed viral load ",

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AU - Molina, Jean Michel

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AU - Chetchotisakd, Ploenchan

AU - Lazzarin, Adriano

AU - Orkin, Chloe

AU - Rhame, Frank

AU - Stellbrink, Hans Jürgen

AU - Li, Taisheng

AU - Crauwels, Herta

AU - Rimsky, Laurence

AU - Vanveggel, Simon

AU - Williams, Peter

AU - Boven, Katia

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