Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials

Calvin J. Cohen, Jean Michel Molina, Isabel Cassetti, Ploenchan Chetchotisakd, Adriano Lazzarin, Chloe Orkin, Frank Rhame, Hans Jürgen Stellbrink, Taisheng Li, Herta Crauwels, Laurence Rimsky, Simon Vanveggel, Peter Williams, Katia Boven

Research output: Contribution to journal › Article

102 Citations (Scopus)

Abstract

Background: In the week 48 primary analysis of ECHO and THRIVE, rilpivirine demonstrated noninferior efficacy and more favourable tolerability versus efavirenz in treatment-naive, HIV-1-infected adults. Pooled 96-week results are presented. Methods: Patients (N1/41368) received rilpivirine 25mg once-daily (q.d.) or efavirenz 600mg q.d., with two background nucleoside/nucleotide reverse transcriptase inhibitors, in two randomized, double-blind, double-dummy Phase III trials. Results: At week 96, response rate (% confirmed viral load

Original languageEnglish
Pages (from-to)939-950
Number of pages12
JournalAIDS (London, England)
Volume27
Issue number6
DOIs
Publication statusPublished - Mar 27 2013

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Rilpivirine
efavirenz
HIV-1
Safety
Reverse Transcriptase Inhibitors
Viral Load
Nucleosides
Nucleotides
Therapeutics

Keywords

  • Efavirenz
  • HIV-1
  • Rilpivirine
  • Treatment naive

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Cohen, C. J., Molina, J. M., Cassetti, I., Chetchotisakd, P., Lazzarin, A., Orkin, C., ... Boven, K. (2013). Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials. AIDS (London, England), 27(6), 939-950. https://doi.org/10.1097/QAD.0b013e32835cee6e

Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials. / Cohen, Calvin J.; Molina, Jean Michel; Cassetti, Isabel; Chetchotisakd, Ploenchan; Lazzarin, Adriano; Orkin, Chloe; Rhame, Frank; Stellbrink, Hans Jürgen; Li, Taisheng; Crauwels, Herta; Rimsky, Laurence; Vanveggel, Simon; Williams, Peter; Boven, Katia.

In: AIDS (London, England), Vol. 27, No. 6, 27.03.2013, p. 939-950.

Research output: Contribution to journal › Article

Cohen, CJ, Molina, JM, Cassetti, I, Chetchotisakd, P, Lazzarin, A, Orkin, C, Rhame, F, Stellbrink, HJ, Li, T, Crauwels, H, Rimsky, L, Vanveggel, S, Williams, P & Boven, K 2013, 'Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials', AIDS (London, England), vol. 27, no. 6, pp. 939-950. https://doi.org/10.1097/QAD.0b013e32835cee6e
Cohen CJ, Molina JM, Cassetti I, Chetchotisakd P, Lazzarin A, Orkin C et al. Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials. AIDS (London, England). 2013 Mar 27;27(6):939-950. https://doi.org/10.1097/QAD.0b013e32835cee6e
Cohen, Calvin J. ; Molina, Jean Michel ; Cassetti, Isabel ; Chetchotisakd, Ploenchan ; Lazzarin, Adriano ; Orkin, Chloe ; Rhame, Frank ; Stellbrink, Hans Jürgen ; Li, Taisheng ; Crauwels, Herta ; Rimsky, Laurence ; Vanveggel, Simon ; Williams, Peter ; Boven, Katia. / Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials. In: AIDS (London, England). 2013 ; Vol. 27, No. 6. pp. 939-950.
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AU - Chetchotisakd, Ploenchan

AU - Lazzarin, Adriano

AU - Orkin, Chloe

AU - Rhame, Frank

AU - Stellbrink, Hans Jürgen

AU - Li, Taisheng

AU - Crauwels, Herta

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AU - Williams, Peter

AU - Boven, Katia

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