Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer: A phase II study

Michele Orditura, Gennaro Galizia, Vincenzo Napolitano, Erika Martinelli, Roberto Pacelli, Eva Lieto, Gaetano Aurilio, Loredana Vecchione, Floriana Morgillo, Giuseppe Catalano, Fortunato Ciardiello, Alberto Del Genio, Natale Di Martino, Ferdinando De Vita

Research output: Contribution to journalArticle

Abstract

We evaluated the association of a weekly cisplatin (35 mg/mq) and paclitaxel (45 mg/mq) regimen with radiotherapy (46 Gy) as primary treatment in locally advanced esophageal cancer (LAEC). The main end point was the activity in terms of pathologic complete response (pathCR) rate. Thirty-three LAEC patients received chemoradiation therapy during weeks 1-6 followed by esophagectomy. A pathCR was observed in 10/33 patients; 20/33 and 3/33 patients showed PR and SD, respectively. The EUS maximal transverse cross sectional area reduction >50 significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen.

Original languageEnglish
Pages (from-to)820-827
Number of pages8
JournalCancer Investigation
Volume28
Issue number8
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Cisplatin
  • Esophageal cancer
  • Paclitaxel
  • Preoperative chemoradiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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    Orditura, M., Galizia, G., Napolitano, V., Martinelli, E., Pacelli, R., Lieto, E., Aurilio, G., Vecchione, L., Morgillo, F., Catalano, G., Ciardiello, F., Genio, A. D., Martino, N. D., & De Vita, F. (2010). Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer: A phase II study. Cancer Investigation, 28(8), 820-827. https://doi.org/10.3109/07357901003630926