Abstract
Background: Obesity exacerbates the age-related decline in physical function and causes frailty in older adults; however, the appropriate treatment for obese older adults is controversial. Methods: In this 1-year, randomized, controlled trial, we evaluated the independent and combined effects of weight loss and exercise in 107 adults who were 65 years of age or older and obese. Participants were randomly assigned to a control group, a weight-management (diet) group, an exercise group, or a weight-management-plus-exercise (diet-exercise) group. The primary outcome was the change in score on the modified Physical Performance Test. Secondary outcomes included other measures of frailty, body composition, bone mineral density, specific physical functions, and quality of life. Results: A total of 93 participants (87%) completed the study. In the intention-to-treat analysis, the score on the Physical Performance Test, in which higher scores indicate better physical status, increased more in the diet-exercise group than in the diet group or the exercise group (increases from baseline of 21% vs. 12% and 15%, respectively); the scores in all three of those groups increased more than the scores in the control group (in which the score increased by 1%) (P
| Original language | English |
|---|---|
| Pages (from-to) | 1218-1229 |
| Number of pages | 12 |
| Journal | New England Journal of Medicine |
| Volume | 364 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - Mar 31 2011 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Weight loss, exercise, or both and physical function in obese older adults. / Villareal, Dennis T.; Chode, Suresh; Parimi, Nehu; Sinacore, David R.; Hilton, Tiffany; Armamento-Villareal, Reina; Napoli, Nicola; Qualls, Clifford; Shah, Krupa.
In: New England Journal of Medicine, Vol. 364, No. 13, 31.03.2011, p. 1218-1229.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Weight loss, exercise, or both and physical function in obese older adults
AU - Villareal, Dennis T.
AU - Chode, Suresh
AU - Parimi, Nehu
AU - Sinacore, David R.
AU - Hilton, Tiffany
AU - Armamento-Villareal, Reina
AU - Napoli, Nicola
AU - Qualls, Clifford
AU - Shah, Krupa
PY - 2011/3/31
Y1 - 2011/3/31
N2 - Background: Obesity exacerbates the age-related decline in physical function and causes frailty in older adults; however, the appropriate treatment for obese older adults is controversial. Methods: In this 1-year, randomized, controlled trial, we evaluated the independent and combined effects of weight loss and exercise in 107 adults who were 65 years of age or older and obese. Participants were randomly assigned to a control group, a weight-management (diet) group, an exercise group, or a weight-management-plus-exercise (diet-exercise) group. The primary outcome was the change in score on the modified Physical Performance Test. Secondary outcomes included other measures of frailty, body composition, bone mineral density, specific physical functions, and quality of life. Results: A total of 93 participants (87%) completed the study. In the intention-to-treat analysis, the score on the Physical Performance Test, in which higher scores indicate better physical status, increased more in the diet-exercise group than in the diet group or the exercise group (increases from baseline of 21% vs. 12% and 15%, respectively); the scores in all three of those groups increased more than the scores in the control group (in which the score increased by 1%) (P
AB - Background: Obesity exacerbates the age-related decline in physical function and causes frailty in older adults; however, the appropriate treatment for obese older adults is controversial. Methods: In this 1-year, randomized, controlled trial, we evaluated the independent and combined effects of weight loss and exercise in 107 adults who were 65 years of age or older and obese. Participants were randomly assigned to a control group, a weight-management (diet) group, an exercise group, or a weight-management-plus-exercise (diet-exercise) group. The primary outcome was the change in score on the modified Physical Performance Test. Secondary outcomes included other measures of frailty, body composition, bone mineral density, specific physical functions, and quality of life. Results: A total of 93 participants (87%) completed the study. In the intention-to-treat analysis, the score on the Physical Performance Test, in which higher scores indicate better physical status, increased more in the diet-exercise group than in the diet group or the exercise group (increases from baseline of 21% vs. 12% and 15%, respectively); the scores in all three of those groups increased more than the scores in the control group (in which the score increased by 1%) (P
UR - http://www.scopus.com/inward/record.url?scp=79953225169&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953225169&partnerID=8YFLogxK
U2 - 10.1056/NEJMoa1008234
DO - 10.1056/NEJMoa1008234
M3 - Article
C2 - 21449785
AN - SCOPUS:79953225169
VL - 364
SP - 1218
EP - 1229
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 13
ER -