Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women

Soraya Taleb, Raffaella Cancello, Christine Poitou, Christine Rouault, Philippe Sellam, Patrick Levy, Jean Luc Bouillot, Christiane Coussieu, Arnaud Basdevant, Michèle Guerre-Millo, Danièle Lacasa, Karine Clement

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Human adipose tissue produces several adipokines, including the newly identified protein cathepsinS(CTSS), a cysteine protease involved in the pathogenesis of atherosclerosis. Obesity is characterized by high levels of CTSS in the circulation and in sc white adipose tissue (scWAT). Objective: We investigated the effect of surgery-induced weight loss on circulating CTSS and its protein expression in scWAT. Design: Fifty morbidly obese women before and 3 months after surgery and 10 healthy lean women were studied. We analyzed the relationships between circulating CTSS and clinical and biological parameters. Immunohistochemistry of the CTSS protein variations in scWAT was performed. Results: Weight loss decreased by 42% (P <0.0001) the circulating CTSS levels, which correlated with changes in body weight (P = 0.03). Weobserved a significant decrease in CTSS enzymatic activity by 25% after weight loss (P = 0.001). Adipose tissue CTSS content was reduced by 30% (P = 0.002) after surgery. The variations in CTSS expression in scWAT after surgery correlated with changes in circulating CTSS serum levels (P = 0.03). Most of the correlations between CTSS and clinical and biological parameters disappeared after adjustment for body mass index, emphasizing the strong link between CTSS and corpulence in humans. Conclusions: Changes in CTSS scWAT might contribute to serum variations in CTSS during weight loss. The decrease in CTSS concentrations in the circulation may contribute to vascular improvement in obese subjects after weight loss.

Original languageEnglish
Pages (from-to)1042-1047
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number3
DOIs
Publication statusPublished - Mar 2006

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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