Welding and lung cancer in a pooled analysis of case-control studies

Benjamin Kendzia, Thomas Behrens, Karl Heinz Jöckel, Jack Siemiatycki, Hans Kromhout, Roel Vermeulen, Susan Peters, Rainer Van Gelder, Ann Olsson, Irene Brüske, H. Erich Wichmann, Isabelle Stücker, Florence Guida, Adonina Tardón, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Hermann Pohlabeln, Wolfgang Ahrens, Maria Teresa LandiNeil Caporaso, Dario Consonni, David Zaridze, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Per Gustavsson, Michael Marcus, Eleonora Fabianova, Andrea't Mannetje, Neil Pearce, Lap Ah Tse, Ignatius Tak Sun Yu, Peter Rudnai, Vladimir Bencko, Vladimir Janout, Dana Mates, Lenka Foretova, Francesco Forastiere, John McLaughlin, Paul Demers, Bas Bueno-De-Mesquita, Paolo Boffetta, Joachim Schüz, Kurt Straif, Beate Pesch, Thomas Brüning

Research output: Contribution to journalArticlepeer-review


Several epidemiologic studies have indicated an increased risk of lung cancer among welders. We used the SYNERGY project database to assess welding as a risk factor for developing lung cancer. The database includes data on 15,483 male lung cancer cases and 18,388 male controls from 16 studies in Europe, Canada, China, and New Zealand conducted between 1985 and 2010. Odds ratios and 95% confidence intervals between regular or occasional welding and lung cancer were estimated, with adjustment for smoking, age, study center, and employment in other occupations associated with lung cancer risk. Overall, 568 cases and 427 controls had ever worked as welders and had an odds ratio of developing lung cancer of 1.44 (95% confidence interval: 1.25, 1.67) with the odds ratio increasing for longer duration of welding. In never and light smokers, the odds ratio was 1.96 (95% confidence interval: 1.37, 2.79). The odds ratios were somewhat higher for squamous and small cell lung cancers than for adenocarcinoma. Another 1,994 cases and 1,930 controls had ever worked in occupations with occasional welding. Work in any of these occupations was associated with some elevation of risk, though not as much as observed in regular welders. Our findings lend further support to the hypothesis that welding is associated with an increased risk of lung cancer.

Original languageEnglish
Pages (from-to)1513-1525
Number of pages13
JournalAmerican Journal of Epidemiology
Issue number10
Publication statusPublished - Nov 15 2013


  • Case-control studies
  • Lung cancer
  • Occupational exposure
  • Welding

ASJC Scopus subject areas

  • Epidemiology


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