What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

Thomas B L Kirkwood, Martin Feder, Caleb E. Finch, Claudio Franceschi, Amiela Globerson, Christian Peter Klingenberg, Kelly LaMarco, Stig Omholt, Rudi G J Westendorp

Research output: Contribution to journalArticlepeer-review

Abstract

Individual organisms show marked variability in life span, even when they are of the same genotype and are raised in a common environment protected from extrinsic hazards. This intrinsic variability of life span is thought to arise from the stochastic nature of the cellular and molecular mechanisms controlling development and ageing. In this article we review what is currently understood about the factors underlying the variability of life span and consider the implications for research that aims to improve the predictability of health in old age.

Original languageEnglish
Pages (from-to)439-443
Number of pages5
JournalMechanisms of Ageing and Development
Volume126
Issue number3
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Ageing
  • Development
  • Environment
  • Errors
  • Genes
  • Longevity
  • Stochastic
  • Variation

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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