What are the cancer risks in BRCA carriers apart from those regarding the breast and the ovary?

F. Di Gaudio, V. Calò, L. la Paglia, L. Bruno, F. Di Piazza, N. Margarese, F. P. Guadagna, G. Guarneri, G. Cicero, G. R. Ricciardi, C. Rolfo Cervetto, G. Cucinella, G. Pantuso, V. Bazan, A. Russo

Research output: Contribution to journalReview article

Abstract

Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose to familial breast and/or ovarian cancer. The lifetime risk of members of families with genetic predisposition depends on the mutations of susceptibility genes. BRCA1 mutations seem to confer the highest risk of developing neoplastic diseases. Apart from breast and ovarian cancer mutations in BRCA, related pathways are supposed to confer a smaller risk for additional cancers (colon, melanoma, pancreas, lymphoma, prostate, liver). All these tumors have an inherited component not necessarily associated with genetic susceptibility to BRCA genes. To date he main focus of this review has been argued still with difficulty. Just a deeper and complete evaluation of the topic will allow to establish how much is the contribution of BRCA mutations in different types of cancers other than breast and ovary.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalCurrent Women's Health Reviews
Volume8
Issue number1
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Ovary
Breast
Ovarian Neoplasms
Mutation
Genetic Predisposition to Disease
Neoplasms
Breast Neoplasms
Germ-Line Mutation
Tumor Suppressor Genes
Colonic Neoplasms
Genes
Prostate
Pancreas
Melanoma
Lymphoma
Liver

Keywords

  • BRCA genes
  • BRCA mutations
  • Cancer risk

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Di Gaudio, F., Calò, V., la Paglia, L., Bruno, L., Di Piazza, F., Margarese, N., ... Russo, A. (2012). What are the cancer risks in BRCA carriers apart from those regarding the breast and the ovary? Current Women's Health Reviews, 8(1), 65-71. https://doi.org/10.2174/157340412799079327

What are the cancer risks in BRCA carriers apart from those regarding the breast and the ovary? / Di Gaudio, F.; Calò, V.; la Paglia, L.; Bruno, L.; Di Piazza, F.; Margarese, N.; Guadagna, F. P.; Guarneri, G.; Cicero, G.; Ricciardi, G. R.; Rolfo Cervetto, C.; Cucinella, G.; Pantuso, G.; Bazan, V.; Russo, A.

In: Current Women's Health Reviews, Vol. 8, No. 1, 02.2012, p. 65-71.

Research output: Contribution to journalReview article

Di Gaudio, F, Calò, V, la Paglia, L, Bruno, L, Di Piazza, F, Margarese, N, Guadagna, FP, Guarneri, G, Cicero, G, Ricciardi, GR, Rolfo Cervetto, C, Cucinella, G, Pantuso, G, Bazan, V & Russo, A 2012, 'What are the cancer risks in BRCA carriers apart from those regarding the breast and the ovary?', Current Women's Health Reviews, vol. 8, no. 1, pp. 65-71. https://doi.org/10.2174/157340412799079327
Di Gaudio, F. ; Calò, V. ; la Paglia, L. ; Bruno, L. ; Di Piazza, F. ; Margarese, N. ; Guadagna, F. P. ; Guarneri, G. ; Cicero, G. ; Ricciardi, G. R. ; Rolfo Cervetto, C. ; Cucinella, G. ; Pantuso, G. ; Bazan, V. ; Russo, A. / What are the cancer risks in BRCA carriers apart from those regarding the breast and the ovary?. In: Current Women's Health Reviews. 2012 ; Vol. 8, No. 1. pp. 65-71.
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