What Are the Targets of Inflammatory Bowel Disease Management

Sara Lega, Marla C. Dubinsky

Research output: Contribution to journalReview article

Abstract

With recent evidence suggesting that keeping the inflammatory process under tight control prevents long-term disability, the aim of treatments in inflammatory bowel disease (IBD) has shifted from symptom control toward the resolution of bowel inflammation. Mucosal healing is currently recognized as the principal treatment target to be used in a "treat to target" paradigm, whereas histologic healing and normalization of biomarkers are being evaluated as potential future targets. Although symptom relief is no longer a sufficient target, patient experience with the disease is of unquestionable importance and should be assessed in the form of patient-reported outcomes, to be used as a co-primary target with an objective measure of disease activity. IBD in is a heterogeneous disease; thus besides defining common treatment targets, every effort should be made to deliver a personalized treatment plan based on the risk factors for disease progression and individual drug metabolism to improve treatment success.

Original languageEnglish
Pages (from-to)1670-1675
Number of pages6
JournalInflammatory Bowel Diseases
Volume24
Issue number9
DOIs
Publication statusPublished - Aug 16 2018
Externally publishedYes

Keywords

  • inflammatory bowel disease
  • mucosal healing
  • treatment targets

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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